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Description medications: Halothane (Phthorothanum)

Halothane (Phthorothanum). 1, 1, 1-Trifluoro-2-chloro-2-brometanyu.

Synonyms: halothane, Narkotan, Fluotan, Anestan, Fluctan, Fluothane, Ftorotan , Halan, Halothane, Halothanum, Narcotan, Rhodialotan, Somnothane.

Colorless, transparent, mobile, easily volatile liquid with odor reminiscent of chloroform, sweet and pungent taste. The density of 1,865 - 1,870. Boiling Point (distillation) 49 + - 51 C. It is soluble in water (0.345%) is mixed with anhydrous alcohol, ether, chloroform, trichlorethylene, oils. The distribution coefficient of oil / water 330. Vapor pressure at a temperature of +20 C was 241, 5 mm Hg. Art.

Halothane does not burn and does not ignite. Its vapors mixed with oxygen and nitrous oxide in the proportions used for anesthesia, explosion-proof, which is a valuable by its properties when used in today's operating room.

Under the influence of light Halothane decomposes slowly, so it is stored in the orange glass bottle; added for stabilization thymol (0.01%).

Halothane is a powerful narcotic drug, it can be used on their own (with oxygen or air) to reach the stage of surgical anesthesia or as a component of combined anesthesia in combination with other drugs, mainly nitrous oxide.

Pharmacokinetic ftorotan different light absorbability of the respiratory tract and a rapid release of light in an unmodified form; only a small part of halothane is metabolized in the body. The drug has a rapid narcotic effect, terminate shortly after the end of inhalation.

For induction of anesthesia begin with the filing of halothane at a concentration of 0.5 vol. % (With oxygen), then for 1, 5 - 3 min increase it to 3 - 4 vol. %. use concentration of 0.5 to maintain surgical anesthesia stage - 2 vol. %.

When using halothane mind off usually within 1-2 minutes after the start of inhalation of vapors. After 3-5 minutes comes surgical anesthesia. After 3 - 5 minutes after the outage ftorotana patients begin to awaken. Anesthesia depression completely disappears in 5 - 10 minutes after a brief and after 30 - 40 minutes after prolonged anesthesia. Excitation occurs rarely and weakly expressed.

halothane vapors do not cause irritation of the mucous membranes. There were no significant changes in gas exchange does not occur when anesthesia halothane; blood pressure usually goes down, partly due to the inhibitory effect of the drug on the sympathetic ganglia and the expansion of periferichesknh vessels. Vagal tone is high, which creates conditions for bradycardia. To some extent, halothane has deprimiruyuschee action on the myocardium. In addition, halothane increases the sensitivity of the myocardium to catecholamines: epinephrine and norepinephrine during anesthesia can cause ventricular fibrillation.

Halothane no effect on renal function; in some cases, possible liver dysfunction with jaundice.