Description of the medicine: Khonsuridum (Chonsuridum)
The drug is obtained from the trachea (hyaline cartilage) of cattle.
A porous mass, white or white with a slight yellowish tint. Easily soluble in water and in an isotonic sodium chloride solution.
The active substance of honsurida is chondroitinsulfuric acid.
Chondroitin sulfuric acid (chondroitin sulfate) is a high molecular weight mucopolysaccharide (relative molecular weight 20,000 to 30,000). It is contained in significant quantities along with hyaluronic acid in various types of connective tissue. Cartilage tissue is especially rich in it, where it is in a free state or is associated with protein substances. Chondroitin sulfates A, B and C are distinguished, similar in chemical structure. Chondroitin sulfates A and C are constructed from molecules of Nacetylgalactosamine-6-sulfate and glucuronic acid, and chondroitin sulfate B from N-acetylgalactosamine-6-sulfate and L-iduronic acid (similar in structure to ascorbic acid).
Chondroitinsulfuric acid along with hyaluronic acid is involved in the construction of the main substance of connective tissue.
Applied externally to accelerate reparative processes with long-term non-healing, sluggishly granulating and slowly epithelizing wounds after injuries and surgical interventions; with trophic ulcers, bedsores (in the granulation stage), etc.
Available in the form of a dry powder in vials of 0.05 - 0.1 g. Immediately before use, 5 or 10 ml (corresponding to the weight of the powder) of a 0.5% novocaine solution or isotonic sodium chloride solution is introduced into the vial. The contents of the vial are thoroughly shaken. The resulting viscous solution is distributed on the surface of a two-layer sterile gauze cloth and applied to the wound; put on top of the usual dressing. Dressings are made 1 time in 2 - 3 days. The duration of treatment, depending on the course of the process, is 10-30 days.
Contraindications: acute inflammatory processes in the wound area, widespread tissue necrosis, excessive granulation.
With pronounced cicatricial changes in the edges of the wound and with excessive granulations, honsurid can be used after treatment with preparations containing hyaluronidase (lidase or ronidase).
Release form: in hermetically closed bottles.
Storage: in a dry, dark place at a temperature of no higher than + 20 'C.