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Medication Description: Chonsuridum

HONSURID (Chonsuridum).

The drug obtained from trachea (hyaline cartilage) of cattle.

White or white with a slight yellowish tinge porous mass. Easily soluble in water and in isotonic sodium chloride solution.

The active ingredient of chonsurid is chondroitin sulfuric acid.

Chondroitin sulfuric acid (chondroitin sulfate) is a high molecular mucopolysaccharide (relative molecular weight 20,000–30,000). Contained in significant quantities along with hyaluronic acid in various types of connective tissue. It is especially rich in cartilage tissue, where it is in a free state or associated with protein substances. There are chondroitin sulfates A, B, and C, which are similar in chemical structure. Chondroitin sulfates A and C are constructed from Na-acetylgalactosamine-6-sulfate and glucuronic acid molecules, and chondroitin sulfate B from N-acetyl-galactosamine-6-sulfate and L-iduronic acid (similar in structure to ascorbic acid).

Chondroitin sulfuric acid along with hyaluronic acid is involved in the construction of the main substance of connective tissue.

Applied externally to accelerate the reparative processes for non-healing, languidly granulating and slowly epithelial wounds after injuries and surgical interventions; with trophic ulcers, bedsores (in the granulation stage), etc.

Available in the form of a dry powder in vials of 0.05-0.1 g. 5 or 10 ml (respectively, the mass of the powder) of a 0.5% solution of novocaine or isotonic sodium chloride solution is injected directly into the vial. The contents of the vial are thoroughly shaken. The resulting viscous solution is spread on the surface of a double-layer sterile gauze cloth and placed on the wound; on top of the usual bandage impose. Ligation produced 1 time in 2 - 3 days. Duration of treatment, depending on the course of the process 10 - 30 days.

Contraindications: acute inflammatory processes in the wound area, widespread tissue necrosis, excessive granulation.

With marked cicatricial changes of the wound edges and with excessive granulation, the Honsurid can be applied after treatment with preparations containing hyaluronidase (with lidaza or ronidase).

Product: in hermetically sealed vials.

Storage: in a dry, dark place at a temperature not higher than + 20 'C.