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Description medications: Tienam (Tienam)

Tien (Tienam) (Company name drug "MERCK & CO., INC.", Rahway NJ , USA).

Tienam is a combination of sodium salts and antibiotic imipinema digidropeptidazy renal enzyme inhibitor (cilastatin) in a ratio of 1: 1.

Cilastatin (Silastatin). [6-Carboxy-6- (2, 2-dimethylcyclopropanecarboxamide) -5-hexenyl] -L-cysteine.

Tienam used for a variety of infections caused by susceptible pathogens to imipenem, with abdominal infections, lower respiratory tract infections, septicemia, infections of urinary tract, infections of the skin, soft tissues, bones and joints. When meningitis tienam use is not recommended.

Enter intravenously. A typical daily dose for adult 1 - 2 g (3 4 doses). In severe infections adult dose may be increased to 4 g per day with further decrease. Administered more than 4 grams per day are not recommended. If the kidney function, the drug is used in small doses - depending on the severity of 0.5 - 0.25 g every 6 - 8 12 hours.

For intravenous tienam available in vials with 60 ml, containing 0.25 g (250 mg), imipenem and cilastatin, 0.25 g, and in 120 ml vials, each containing 0.5 g of imipenem and cilastatin 0.5 g. Dissolved in sodium hydrogencarbonate buffer solution. Dose of 0.25 g, is diluted in 50 ml of solvent, and the dose of 0.5 g - 100 ml of solvent. Enter in the vein slowly - for 20 - 30 minutes. At a dose of 1 g, the introduction of the solution produced for 40 - 60 min.

Children weighing more than 40 kg tienam administered in the same dose as adults, and weighing less than 40 kg - a rate of 15 mg / kg at intervals of 6 hours.

The total daily dose should not exceed 2 years Children up to 3 months tienam not appointed.

For drip tienama diluted solution in isotonic sodium chloride solution or 5% glucose solution.

tienama solution administered intramuscularly if necessary. The usual adult dose of 0.5 -. 0.75 g every 12 hours daily dose should not exceed 1, 5 grams injected deep into the muscle. For intramuscular injection, the drug is available in vials containing 0.5 or 0.75 g of imipenem and cilastatin the same amount. Apply solvent (2 - 3 ml), to which is added a solution of lidocaine. At a dilution of a suspension of white or slightly yellowish.

Possible side effects are basically the same as when applying cephalosporins.

Storage: powder - in vials at room temperature. The solutions were prepared to an isotonic sodium chloride solution may be stored at room temperature (25 C) for 10 hours in a refrigerator (+ 4 "C.) - 48 h solutions tienama prepared 5% glucose solution, respectively for 4 or 24 hr. The finished slurry should be used within one hour.

Tienama solutions should not be mixed with other antibiotic solutions.