Description medicines: Gentamicin Sulfate (Gentamycini sulfas)

Gentamicin Sulfate (Gentamycini sulfas).

An antibiotic produced by Micromonospora purpurea; Gentamicin is a mixture of C 1, C 2 and C 1 a.

Synonyms: Garamitsin, Birocin, Celermicin, Cidomycin, Garamycin , Garasol, Gentabiotic, Gentalyn, Gentamin, Gentaplen, Gentocin, Geomycine, Lidogen, Miramycin, Quilagen, Rebofacin, Ribomicin, Sulgemicin, Sulmycin, Violyzen et al.

White powder or porous mass with kremovatym. Easily soluble in water, practically insoluble in alcohol.

It refers to a group of antibiotics-aminoglycosides. It has bacteriostatic action against many Gram-positive and Gram-negative organisms, including Proteus, E. coli, Salmonella, and others. It acts on staphylococci strains resistant to penicillin. Microbial resistance to gentamicin develops slowly, but strains resistant to kanamycin and neomycin, is also resistant to the antibiotic (cross-resistance.).

The drug is rapidly absorbed when administered intramuscularly. After injection of a therapeutic dose of the bactericidal concentration in the blood during 8 - 12 hours.

Provided kidneys in high concentrations in unchanged form.

Apply gentamicin in various infectious diseases caused by microorganisms sensitive to it (pneumonia, bronchopneumonia, pleurisy, empyema, peritonitis, meningitis, septicemia, wound infections, and others.). The drug is effective in urinary tract infections (chronic pyelonephritis, cystitis, urethritis), prostatitis.

Gentamicin is one of the main means of combating severe purulent infection, particularly caused by resistant gram-negative flora. Due to the wide range of action, gentamicin often prescribed for a mixed infection, as well as in cases where the pathogen is not set (usually in combination with semi-synthetic penicillins, ampicillin, carbenicillin, etc.).

In some cases, lack of effective for gentamicin activity of other antibiotics.

Apply gentamicin sulfate injection, intravenous (drip) and locally.

If urinary tract infection single dose for adults and children over 14 years is 0.4 mg / kg daily 0.8 - 1, 2 mg / kg. Patients with severe infectious disease daily dose may be increased to 3 mg / kg. In sepsis and other serious infections (. Peritonitis, lung abscess, etc.) a single dose for adults and children over 14 years is 0.8 - 1 mg / kg, daily 2, 4 - 3, 2 mg / kg. The maximum daily dose - 5 mg / kg.

young children the drug is prescribed only for health in severe infections. The daily dose for newborn infants and children is 2 - 5 mg / kg, 1 - 5 years - 1, 5 - 3 0 mg / kg 6 - 14 - 3 mg / kg. The maximum daily dose for children of all ages - 5 mg / kg. The daily dose is administered 2 - 3 doses. The average duration of treatment is 7 - 10 days. Intravenous injection is made within 2 - 3 days, and then transferred to a local administration.