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Description of the medicine: Buspirone (Buspirone)
BUSPIRON (Buspirone).
8- [4- [4- (2-pyrimidinyl) -1-piperazinyl] butyl] -8-azaspiro [4.5] decane-7,9-dione.
Synonyms: Buspar, Spitomin, Bespar, Buspar, Spitomin
It differs from benzodiazepine tranquilizers by selective anxiolytic (anti-anxiety) action, does not possess anticonvulsant and miorealaxant properties, causes less pronounced sedative effect.
The mechanism of action is not sufficiently elucidated.
When ingested quickly and completely absorbed, although bioavailability is only 4%, Cmax - 40-90 min, T1 / 2 - 2-3 hours; Is subjected to intensive biotransformation in the liver with the formation of an active metabolite (1-pyrimidinylpiperazine).
It is used mainly for the treatment of anxiety conditions.
Assign inside, starting with 0.005 g (5 mg) 2-3 times a day, gradually increase the dose by 0.005 g (5 mg) every 2-3 days until the desired effect is achieved. The maximum daily dose of 0.06 g (60 mg).
The drug is usually well tolerated. Dyspepsia, chest pain, depression, muscle weakness, dizziness, fever, the appearance of a feeling of anxiety and rarely - "blurring" of vision, insomnia, hallucinations, etc., are possible.
The drug is contraindicated in severe violations of the liver and kidneys.
Buspirone is not recommended for children and adolescents under the age of 18 years (due to lack of sufficient data).
Form release: tablets of 0.005 and 0.01 g (5 and 10 mg) (N. 10.60).
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