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Description Cures: Melatonin (Melatonin)

Melatonin (Melatonin).

N- [2- (5-Methoxy-1H-indol-5-yl) ethyl] atsetilamid or N-acetyl-5-methoxytryptamine.

Synonyms: melaxen, Melapur, Melaton, Yukalin, Eucalin, Melapur, Melatonum, Melaxen and others.

Powder. Soluble in water and alcohol.

The chemical structure is very similar to serotonin (5-hydroxytryptamine) and mexamine (is O-methylated and N-acetylated derivative of serotonin).

This endogenous compound produced by the pineal gland (pineal gland) brain.
The physiological role of melatonin is known enough. He is believed to play a role "synchronizer" biological functions (sleep phases, the circadian oscillation of metabolism, immune responses, and others.). There is evidence of its anti-stress and adaptogenic activity.

The name "melatonin" is associated with the detected in experiments with frogs ability substances stimulate the function of melanophores and enhance skin pigmentation. Under the influence of ambient light also changes the speed of the biosynthesis of endogenous melatonin.

Melatonin is produced synthetically, and in recent years attempts to use it as a drug. It is proposed to use melatonin to regulate sleep rhythm, especially in cases of violation by changing the time zone (when flying over long distances), and other disorders of the sleep cycle; as adaptogenic resources at high loads on the body and other conditions. Finally spectrum of therapeutic action of melatonin has not been determined. In some countries it is recommended as a dietary supplement.

Assign inside (preferably at bedtime). The usual recommended dose of 0.003 g (3 mg).

The maximum daily dose of 0.006 g (6 mg).

Possible side effects include morning drowsiness, edema.

Melatonin is contraindicated in severe impaired renal function, autoimmune diseases, leukemia, lymphoma, pregnancy, breastfeeding.

It enhances the effects of drugs which depress the central nervous system.

Product form: tablets of 0.003 g (3 mg) (N. 2, 6, 12, 24, 30, 60).

Available dosage forms (capsules, tablets) comprising melatonin together with other drugs.

Yukalin - pills to 0,003 grams (3 mg) of melatonin - is offered as an adaptogen; tablets of melatonin 0.003 g and 0.001 g of powdered valerian root - a sedative.

APIC-melatonin - tablets of 0.003 g of melatonin and 0.01 g of pyridoxine (vitamin B 6).