Description of the medicine: Enoxaparin sodium (Enoxaparine sodium)

ENOXAPARINE SODIUM (Enoxaparine sodium).

Synonyms: Clexan, Klexan, Lovenox.

The drug is a low molecular weight heparin with a molecular weight of about 4500 daltons.

Linking with antithrombin III (endogenous inhibitor of blood coagulation) sodium enoxaparin potentiates its inhibitory effect on the formation and activity of factor Xa, which, in turn, leads to a decrease in the formation of thrombin. In sodium enoxyparin, the ratio of antithrombotic and anticoagulant activity (activity of Xa and IIa antifactors) is approximately 3: 1 compared to 1: 1 in unfractionated heparin.

When subcutaneously injected quickly and completely absorbed, C _max , as well as the peak inhibitory activity against factor Xa, is noted after 3-5 hours; T _S -47 h; Is excreted by the kidneys.

Used in surgical and orthopedic practice for the prevention of thromboembolism; With deep vein thrombosis, pulmonary embolism, acute coronary insufficiency, and also to prevent hypercoagulation in the extracorporeal circulation system during hemodialysis.

According to published foreign data, in patients with unstable angina and myocardial infarction, enoxaparin sodium in combination with acetylsalicylic acid was short-term (14-30 days) superior to unfractionated heparin (also in combination with acetylsalicylic acid) by the ability to reduce the incidence of angina attacks, repeated myocardial infarctions, Hospitalizations, myocardial revascularization and other complications.

Enter subcutaneously (in the anterolateral or posterolateral area of ​​the abdominal wall) and sometimes intravenously.

For prophylaxis of deep vein thrombosis and pulmonary artery thromboembolism in surgical interventions at moderate and high risk, respectively, 2000 and 4000 IU (0.02 and 0.04 g) 2 hours before the operation, then 1 time per day for 7-10 Day; Therapeutic patient - 4000 IU (0.04 g) once a day for 6-14 days.

In the treatment of advanced deep vein thrombosis and pulmonary embolism, 150 IU / kg (1.5 mg / kg) are administered once a day for at least 5 days with the transition to indirect anticoagulants.

For unstable angina and myocardial infarction without a Q wave, 100 IU / kg (1 mg / kg) is administered 2 times a day for 2-8 days (the first subcutaneous injection may be preceded by intravenous administration of the drug at a dose of 0.03 g (30 mg) .