Description of the medicine: Loperamide (Loperamidum)
LOPERAMID (Loperamidum). 4- (4-Chlorophenyl) -4-hydroxy-N, N-dimethyl-aa-diphenyl-1-piperidine-butanamide hydrochloride.
Synonyms: Imodium, Capent, Diacure, Diaremide, Donafan, Election, Enterol, Entosec, Imodium, Imosec, Lopemid, Loperan, Loperamide hydrochloride, Lormide, Motilan, Normotil, Obstar, Oldon, Regulane, Suprasec, Vacontil, Viltar, etc.
Flavourless white powder, bitter taste.
The chemical structure is close to phenylpiperidine derivatives, has elements of similarity with analgesics fentanyl and pyritramide (see), but loperamide does not have a pronounced analgesic effect. However, it actively inhibits intestinal motility, which is one of the characteristic features of opiates. Under experimental conditions, loperamide binds to opiate receptors; it is possible that binding to these receptors in the intestinal tissues determines its antidiarrheal effect.
Loperamide is used as a symptomatic agent in acute and chronic diarrhea.
Assign inside adults with acute diarrhea, first 0.004 g (4 mg = 2 capsules), then after each loose stool 0.002 g (1 capsule). Children over 5 years old are given at first 1 capsule (0.002 g), then also 1 capsule after each stool.
In chronic diarrhea, adults are given at first 0.004 g, then 0.002 g from 1 to 6 times a day; Children over 5 years of age are prescribed at first 0.002 g, then also 0.002 g 1-3 times 5 times a day.
For children aged 1 year to 5 years, the drug is given in the form of a solution containing 0.2 mg in 1 ml, 1 teaspoon (5 ml) per 10 kg of body weight 2 to 3 times a day. For children under the age of 1 year, the drug is not prescribed.
When using loperamide (often long), constipation, nausea, dizziness are possible. In these cases, stop taking the drug.
It is not recommended to prescribe loperamide together with atropine and other anticholinergic drugs (in order to avoid mutual enhancement of effects).
Method of release: capsules of 2 mg (0.002 g) in a package of 10 pieces; 0.002% solution of loperamide in 100 ml vials (0.2 mg in 1 ml).
Storage: List B. In the dark place.