Medication Description: Loperamide (Loperamidum)
LOPERAMID (Loperamidum). 4- (4-Chlorophenyl) -4-hydroxy-N, N-dimethyl-aa-diphenyl-1-piperidine-butanamide hydrochloride.
Synonyms: Imodium, Capent, Diacure, Diaremide, Donafan, Election, Enterol, Entosec, Imodium, Imosec, Lopemid, Loperan, Loperamide hydrochloride, Lormide, Motilan, Normotil, Obstar, Oldon, Regulane, Suprasec, Vacontil, Viltar, etc.
White powder, odorless, bitter taste.
The chemical structure is close to the derivatives of phenylpiperidine, has elements similar to analgesics fentanyl and pyritramide (see), but loperamide does not have a pronounced analgesic effect. At the same time, it actively inhibits intestinal peristalsis, which is one of the characteristic features of opiates. Under the experimental conditions, loperamide binds to opiate receptors; It is possible that binding to these receptors in the tissues of the intestine determines its anti-binding effect.
Loperamide is used as a symptomatic remedy for acute and chronic diarrhea.
Assign inside adults with acute diarrhea first 0.004 g (4 mg = 2 capsules), then after each liquid stool 0.002 g (1 capsule). Children over 5 years old are given 1 capsule first (0.002 g), then also 1 capsule after each stool.
In chronic diarrhea, adults give first 0.004 g, then 0.002 g from 1 to 6 times a day; children older than 5 years old are prescribed at the beginning 0.002 g, then also 0.002 g 1 - 3 - 5 times a day.
Children aged 1 to 5 years, the drug is given in the form of a solution containing 0.2 mg in 1 ml, 1 teaspoon (5 ml) per 10 kg of body weight 2 to 3 times a day. Children under the age of 1 year, the drug is not prescribed.
With the use of loperamide (often prolonged), constipation, nausea, dizziness are possible. In these cases, stop taking the drug.
It is not recommended to prescribe loperamide together with atropine and other anticholinergic drugs (in order to avoid mutual enhancement of effects).
Method of production: capsules of 2 mg (0.002 g) in a package of 10 pieces; 0.002% solution of loperamide in bottles of 100 ml (0.2 mg in 1 ml).
Storage: List B. In the dark spot.