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Description medications: Etaperazin (Aethaperazinum)

Etaperazin (Aethaperazinum). 2-Chloro-10- {3- [1- (b - hydroxyethyl) - 4-piperazinyl] - propyl) -fenotiazina dihydrochloride.

Synonyms: perphenazine, Chlorpiprazin, Chlorpiprozine, Decentan, Fentazin , Neuropax, Perphenan, Perphenazini hydrochloridum, Perphenazine hydrochloride, Trilafon, Trilifan and others.

White or white with a barely noticeable grayish white crystalline powder. Easily soluble in water, a little - in alcohol. Hygroscopic. Powder, and aqueous solutions are degraded by light.

Chemical structure different from meterazina presence on the nitrogen atom at position 4 of the piperazine nucleus hydroxyethyl group instead of methyl.

Etaperazin an active antipsychotic agent. It is much more active than chlorpromazine, for antiemetic effect and the ability to calm hiccups. It has a muscle-relaxing effect. Several smaller than chlorpromazine, potentiates the effects of sleeping pills, drugs and other substances that have a depressant effect on the central nervous system; hypothermic action is expressed in a slight degree; slightly inferior aminazinu on adrenoliticheskoy activity. It has kataleptogennoe action.

By the force of action of antipsychotic chlorpromazine and superior approaches triftazinu. In connection with a strong antipsychotic activity etaperazin may be effective in patients resistant to aminazinu. Antipsychotic effect from etaperazina combined with a pronounced activating effect and a selective effect on the syndrome, occurring with retardation, lethargy, apathy, especially with substuporoznyh phenomena, as well as apatoabulicheskie state.

Etaperazin can also be used in the neuroses, accompanied by fear, stress and so on. N.

One of the most important indications for the use etaperazina are uncontrollable vomiting and hiccups. As an antiemetic used after surgery on the abdominal organs, with radiation and chemotherapy of malignant tumors, and so on. N.

In dermatological practice is sometimes prescribed for skin itch.

Etaperazin appointed interior in the form of tablets after meals. Persons with mental illness have not those treated with neuroleptics, establish a starting dose of 0.004 - 0.01 g (4 - 10 mg), 1 - 2 times a day. When excited, and rapid growth of psychotic phenomena daily dose may reach 30 - 40 mg. In the future, gradually increase the dose, selecting her individually for each patient. Patients first starting treatment with neuroleptics, the optimal daily dose is usually 50 to 80 mg (2 - 3 admission). Patients with chronic disease daily dose is adjusted to 0.1 - 0.15 g, and in particularly resistant cases to 0.25 - 0.3 g (sometimes 0.4 g). The duration of treatment is from 1 to 4 months or more. Supportive therapeutic dose - typically 0.01 - 0.06 g (10 - 60 mg) per day.

Etaperazin treatment can be carried out in combination with other psychotropic drugs.