Description medications: Nitrosorbid (Nitrosorbidum)

Nitrosorbid (Nitrosorbidum). 1, 4, 3, 6-dianhydro-D-sorbitol dinitrate.

Cinonimy: Izoket, Izodinit, Kornilat, Lomilan, Armadan, Carvanil, Carvasin, Cornilat, Corodil, Coronex, Difutrat, Isodinit, Isodril, Isoket, Isonit, Isorbid, Isosorbide dinitrate, Isosorbidi dinitras, Isotrate, Lomilan, Metronitron, Nitrsosid, Rigedal, Risordan, Sorbangil, Sorbidilat, Vascardyn, Vasodilat, Vasorbate and others.

The white crystalline powder. Practically insoluble in water, it is difficult - in alcohol.

Nitrosorbide is a basic organic nitrates antianginal for oral administration. In the form of special formulations manufactured for sublingual, intravenous and inhalation applications.

When administered in tablet form Nitrosorbid onset of action observed after 30 - 50 minutes, the maximum effect - 1 through 5 - 2 hours, the total duration of action - 4 - 6 hours or more.

Nitrosorbid widely prescribed as anti-anginal agents in chronic coronary artery disease to prevent attacks; with infrequent attacks of stable angina. Food typically takes up to 0,005 - 0,01 g (5 - 10 mg) of 3 - 4 times daily. Sometimes patients require higher single doses (20 to 30 mg) (According to existing data, in order to prevent the development of tolerance is expedient to take nitrosorbid 30 mg 2 times a day: at 8 am and 13 am, ie during the hours of "overlapping.. "period of the greatest physical activity. From 13 hours to 8 hours of the day following morning restored sensitivity to the drug.).

The applied sublingually (as conventional tablets) nitrosorbid can stop an attack of angina pectoris, but slower than nitroglycerin (after 3 - 5 minutes).

In recent years nitrosorbid like nitroglycerin, it has become used as a peripheral vasodilator in severe heart failure. By lowering the tone of the peripheral veins (venules), the drug reduces venous blood flow to the heart, the pressure in the pulmonary vessels, wheezing, dyspnea, cyanosis. Take it inside of 20 mg (2 tablets) every 4 - 5 hours.

Sometimes prescribed for endarteriite and other diseases involving peripheral vascular spasms.

Possible side effects: headache, dizziness, nausea, are in dose reduction.

Indications are the same as for nitroglycerin.

With prolonged use may develop tolerance Nitrosorbid, in connection with what is recommended after 3 - 6 weeks of regular intake of tablets to take a break for 3 - 5 days, replacing the time nitrosorbid other antianginal drugs.

Product: pills to 0,005; 0.01, and 0.02 g (5, 10 and 20 mg).

Storage: List B. In a cool, dry, dark place away from the fire.

Izodinit (Bulgaria) is available in tablet form: oral (10 mg); sublingual tablets (2, 5 mg of isosorbide dinitrate in the tablet) of tablets for chewing (10 mg per tablet) and retard tablets Izodinit (20 mg per tablet) and 0.1% solution for injection in vials of 10 ml (10 mg).

In addition, overseas drugs produced aerosol form Nitrosorbid "Izomak Spray" (Isomac-spray), and others.