Medication Description: Chorionic Gonadotropin (Gonadotropinum chorionicum)
Gonadotropin chorionic (Gonadotropinum chorionicum).
Synonym: Chorionic gonadotropin.
Chorionic gonadotropin for injection (Gonadotropinum chorionicum pro injectionibus). Release in sterile lyophilized form. White or almost white powder; its solutions are unstable; they are prepared immediately before use in an isotonic solution of sodium chloride.
The hormone activity is determined biologically. One unit of action (ED) corresponds to an activity of 0.1 mg of standard chorionic gonadotropin powder.
Abroad chorionic hormone drugs are available under the names Horiogonin, Antelobine, Choriogoninum, Entromone, Follutein, Gonabion, etc.
Apply with a decrease in the function of the sex glands in men and women, due to impaired activity of the hypothalamus and pituitary. The drug is shown to patients with interstitial - pituitary insufficiency (Simmonds disease, Shien's syndrome, panhypopituitarism of any etiology, adiposogenital dystrophy, pituitary dwarfism with the phenomenon of sexual infantilism, hypogonadotropic hypogonadism with euphony, and hypothyroidism); habitual and threatened abortion in the first trimester of pregnancy, with dysfunctional uterine bleeding in women of childbearing age; in bilateral cryptorchidism in children, as well as in unilateral cryptorchidism after surgical treatment in the presence of signs of eunuchoidism. The drug is also used for the differential diagnosis of primary and secondary hypogonadism in men.
Chorionic gonadotropin is administered intramuscularly in doses of 500 to 3000 units per day (depending on the nature and severity of the disease, the age of the patient).
Men are administered 2 to 3 times a week in courses of 4 weeks at intervals of 4 to 6 weeks. Conduct 3 - 6 courses for 6 - 12 months.
For women with anovulatory cycles with a high level of estrogen, from 10 to 12 days of the cycle, 3000 IU are administered 2 to 3 times at intervals of 2 to 3 days or 1500 IU to 6 to 7 times a day.
When treating interstitial-pituitary insufficiency, chorionic gonadotropin is recommended after prior use (in the first phase of the cycle) of follicle-stimulating hormone.
In case of pituitary nanism, 600-1000 IU is administered 1–2 times a week for 1–2 months by repeated courses. In children with cryptorchidism, treatment is most effective at the age of 10 years, inject 500 to 1000 U (at the age of 10 to 14 years - 1500 EU) 2 times a week for 4 to 6 weeks by repeated courses or continuously for 4 to 5 months
Possible side effects of allergic reactions; excessive enlargement of the testicles in the inguinal canal, which may prevent their further descent; with an overdose of the drug in women, ovarian hyperstimulation is possible with an increase in their size.
Chorionic gonadotropin is contraindicated in inflammatory diseases and genital tumors.