Description of the medicine: Chorionic gonadotropin (Gonadotropinum chorionicum)
GONADOTROPIN CHORIONIC (Gonadotropinum chorionicum).
Synonym: Chorionic gonadotropin.
Chorionic gonadotropin for injection (Gonadotropinum chorionicum pro injectionibus). They are released in sterile lyophilized form. White or almost white powder; its solutions are unstable; they are prepared immediately before use on an isotonic sodium chloride solution.
The activity of the hormone is determined biologically. One unit of action (UNIT) corresponds to an activity of 0.1 mg of standard human chorionic gonadotropin powder.
Abroad, chorionic hormone preparations are available under the names Choriogonin, Antelobine, Choriogoninum, Entromone, Follutein, Gonabion, etc.
Applied with a decrease in the function of the sex glands in men and women, due to a violation of the hypothalamus and pituitary gland. The drug is indicated for patients with interstitial pituitary insufficiency (Simmonds disease, Shien's syndrome, panhypopituitarism of any etiology, adipozogenital dystrophy, pituitary dwarfism with the phenomena of sexual infantilism, hypogonadotropic hypogonadism with eunuchoidism, non-ovulatory and non-ovulatory dysfunctional habitual and threatening abortion in the first trimester of pregnancy, with dysfunctional uterine bleeding in women of childbearing age; with bilateral cryptorchidism in children, as well as with unilateral cryptorchidism after surgical treatment in the presence of signs of eunuchoidism. The drug is also used for the differential diagnosis of primary and secondary hypogonadism in men.
Chorionic gonadotropin is prescribed intramuscularly in doses from 500 to 3000 units per day (depending on the nature and severity of the disease, the age of the patient).
Men are injected 2 to 3 times a week in courses of 4 weeks at intervals of 4 to 6 weeks. Conduct 3-6 courses for 6-12 months.
Women with anovulatory cycles with a high level of estrogen are administered, starting from the 10-12th day of the cycle, 3000 units 2-3 times at intervals of 2-3 days, or 1500 units 6-7 times every other day.
In the treatment of interstitial-pituitary insufficiency, chorionic gonadotropin is recommended after the preliminary use (in the first phase of the cycle) of follicle-stimulating hormone.
With pituitary nanism, 600-1000 units are administered 1 to 2 times a week for 1 to 2 months with repeated courses. With cryptorchidism in children, treatment is most effective under the age of 10 years, 500 to 1000 units are administered (at the age of 10 to 14 years - 1500 units) 2 times a week for 4 to 6 weeks with repeated courses or continuously for 4 to 5 month
Possible side effects are allergic reactions; excessive enlargement of the testicles in the inguinal canal, which may impede their further lowering; with an overdose of the drug in women, ovarian hyperstimulation is possible with an increase in their size.
Chorionic gonadotropin is contraindicated in inflammatory diseases and tumors of the genital area.