Description of the medicine: Riboflavin (Riboflavinum)
VITAMIN B 2 (Vitaminum B 2). 6, 7-Dimethyl-9- (D-1-ribityl) isoalloxazine.
Synonyms: Beflavin, Beflavit, Betavitam, Flavaxin, Flavitol, Lactobene, Lactoflavin, Ovoflavin, Ribovin, Vitaflavine, Vitaplex B2, etc.
A yellow-orange crystalline powder of a bitter taste, with a faint specific odor. Unstable in the world. Slightly soluble in water and alcohol. Aqueous solutions are yellow in color and have intense yellowish green fluorescence; The pH of the solutions is 5, 0 - 7, 0. Sterilized at +100 ° C for 30 minutes.
Vitamin B 2 is widespread in the plant and animal world. It enters the human body mainly with meat and dairy products. It is found in yeast, whey, egg white, meat, fish, liver, peas, embryos and shells of crops. Obtained also synthetically.
Upon entry into the body, riboflavin interacts with adenosine triphosphoric acid and forms flavin mononucleotide and flavin adenine nucleotide. The latter are prosthetic groups (coenzymes) of flavinproteins and are involved in the transfer of hydrogen and the regulation of redox processes. Riboflavin is involved in the processes of carbohydrate, protein and fat metabolism; it also plays an important role in maintaining the normal visual function of the eye and in the synthesis of hemoglobin.
With a reduced content or absence of vitamin B 2 in food, a person develops hyporiboflavinosis, and then ariboflavinosis. With hyporiboflavinosis, a decrease in appetite, a decrease in body weight, weakness, headache, a burning sensation of the skin, pain in the eyes, impaired twilight vision, pain in the corners of the mouth and lower lip are noted. With the development of the disease, cracks and crusts appear in the corners of the mouth (the so-called angular stomatitis), the tongue becomes dry, bright red, seborrheic dermatitis of the nasolabial folds develops; photophobia, conjunctivitis, blepharitis appear.
The daily need for vitamin B 2 is about 2.5 mg for an adult, and about 3 mg for heavy physical labor; for children from 6 months to 1 year - 0.6 mg; from 1 year to 1, 5 years 1, 1 mg; from 1, 5 to 2 years - 1, 2 mg; from 3 to 4 years - 1, 4 mg; from 5 to 6 years - 1, 6 mg; from 7 to 10 years - 1, 9 mg; from 11 to 13 years - 2, 3 mg; for boys 14-17 years old - 2.5 mg; for girls 14 - 17 years old - 2, 2 mg.
For medicinal purposes, riboflavin is used for hypo- and ariboflavinosis, for hemeralopia, conjunctivitis, iritis, keratitis, corneal ulcers, cataracts, for long-term non-healing wounds and ulcers, general malnutrition, radiation sickness, asthenia, impaired bowel function, sprue, and intestine dysfunction, sprue, and other diseases.
Riboflavin is prescribed orally in powders, tablets, dragees and in the form of eye drops (0.01% solution).
A single therapeutic dose for oral administration is for adults 0.005 - 0.01 g (5 - 10 mg) per day, in more severe cases - 0.01 g 3 times a day (for 1 - 1, 5 months). Children are prescribed 0.002 - 0.005 g and up to 0.01 g per day, depending on age.
Excreted by the kidneys. After ingestion (or by injection), riboflavin (and riboflavin mononucleotide) stains urine in a light yellow color.