Medication Description: Riboflavinum (Riboflavinum)
VITAMIN 2 (Vitaminum 2). 6,7-Dimethyl-9- (D-1-ribityl) -isoalloxazine.
Synonyms: Beflavin, Beflavit, Betavitam, Flavaxin, Flavitol, Lactobene, Lactoflavin, Ovoflavin, Ribovin, Vitaflavine, Vitaplex B2, etc.
Yellow-orange crystalline powder of a bitter taste, with a slight specific smell. In the light of unstable. It is soluble in water and alcohol. Aqueous solutions have a yellow color and intense yellowish green fluorescence; pH of the solutions is 5, 0 - 7, 0. Sterilized at +100 'C for 30 minutes.
Vitamin b 2 is widely distributed in the plant and animal world. In the human body enters mainly with meat and dairy products. Contained in yeast, whey, egg white, meat, fish, liver, peas, germ and skins of grain crops. Also obtained synthetically.
When entering the body, riboflavin interacts with adenosine triphosphoric acid and forms flavin mononucleotide and flavinadenine nucleotide. The latter are prosthetic groups (coenzymes) of flavinproteins and are involved in the transfer of hydrogen and the regulation of redox processes. Riboflavin is involved in the processes of carbohydrate, protein and fat metabolism; it also plays an important role in maintaining the normal visual function of the eye and in the synthesis of hemoglobin.
With a reduced content or absence of vitamin B 2 in food, a person develops hyporiblavinosis, and then ariboflavinosis. In hyporiblavinosis, a decrease in appetite, weight loss, weakness, headache, burning sensation of the skin, pain in the eyes, blurred vision, pain in the corners of the mouth and lower lip are noted. With the development of the disease, cracks and crusts appear in the corners of the mouth (the so-called angular stomatitis), the tongue becomes dry, bright red, seborrheic dermatitis of the nasolabial folds develops; photophobia, conjunctivitis, blepharitis appear.
The daily need for vitamin b 2 is for an adult about 2, 5 mg, with heavy physical labor - about 3 mg; for children from 6 months to 1 year - 0.6 mg; from 1 year to 1, 5 years 1, 1 mg; from 1, 5 to 2 years - 1, 2 mg; from 3 to 4 years - 1, 4 mg; from 5 to 6 years - 1, 6 mg; from 7 to 10 years - 1, 9 mg; from 11 to 13 years - 2, 3 mg; for boys 14 - 17 years old - 2, 5 mg; for girls 14 - 17 years old - 2, 2 mg.
For therapeutic purposes, riboflavin is used for hypo- and ariboflaviosis, for hemeralopia, conjunctivitis, iritis, keratitis, corneal ulcers, cataracts, for non-healing wounds and ulcers, general nutritional disorders, radiation sickness, diseases of the intestines, sphru, diseases of the organism, common disorders of the diet, radiation sickness, diseases of the intestines, sphara, diseases of the disease, diseases of the general diet, radiation sickness, asthenia, disorders of bowel function, sphru and other diseases.
Assign riboflavin inside in powders, tablets, dragees and in the form of eye drops (0.01% solution).
A single therapeutic dose for oral administration is 0.005-0.01 g (5-10 mg) per day for adults, and in more severe cases, 0.01 g 3 times a day (for 1-1.5 months). Children are prescribed at 0.002 - 0.005 g and up to 0.01 g per day, depending on age.
Excreted from the body by the kidneys. After ingestion (or by injection), riboflavin (and riboflavin mononucleotide) stains the urine in a light yellow color.