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Description of the medicine: Pyridoxine (Pyridoxinum)

Pyridoxine (Pyridoxinum).

VITAMIN B6 (Vitaminum B6).

Synonyms: Adermin, Beadox, Becilan, Bedoxin, Benadon, Besatin, Hexabetalin, Hexabion, Hexavibex, Pyrivitol, etc.

The activity of vitamin B6 has a group of compounds derived from pyridine, united by the common name "pyridoxine" and differing from each other with substituents in position 4.

The compound in which R = CH 2 OH is called "pyridoxine", with R = CHO - "pyridoxal", with R = CH 2 NH 2 - "pyridoxamine".

Pyridoxine hydrochloride (Ruridoxini hydrochloridum) is available for medical use. 2-Methyl-3-hydroxy-4, 5-di- (oxymethyl) pyridine hydrochloride.

Flavourless white crystalline powder, bitter-sour taste. Easily soluble in water, difficult - in alcohol; The pH of a 1% aqueous solution is 2, 5 - 3, 5. The solutions are sterilized at a temperature of +100 C for 30 minutes. Under the influence of light in aqueous solutions is destroyed.

Vitamin B 6 is found in plants and animal organs, especially in unrefined grains of cereal crops, in vegetables, meat, fish, milk, cod liver and cattle, egg yolk. Relatively high levels of vitamin B6 in yeast. The need for vitamin B 6 is met by food; it is also partially synthesized by intestinal microflora.

Pyridoxine plays a large role in metabolism. It is necessary for the normal functioning of the central and peripheral nervous system. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate and is part of the enzymes involved in decarboxylation and transamination of amino acids. Pyridoxine is actively involved in the exchange of tryptophan, methionine, cysteine, glutamine and other amino acids. It also plays an important role in histamine metabolism.

Pyridoxine is involved in the processes of fat metabolism. Improves lipid metabolism in atherosclerosis.

The daily need for pyridoxine for adults is about 2 - 2.5 mg; for children from 6 months to 1 year - 0.5 mg; from 1 year to 1, 5 years - 0.9 mg; from 1, 5 to 2 years - 1 mg; from 3 to 4 years - 1, 3 mg; from 5 to 6 years - 1, 4 mg; from 7 to 10 years - 1, 7 mg; 11 to 13 years 2 mg; for boys 14-17 years old - 2, 2 mg; for girls 14 - 17 years old 1, 9 mg.

Pyridoxine is used for various diseases: In 6-hypovitaminosis, toxicosis of pregnant women; anemia (especially with sideroblastic anemia), leukopenia of various etiologies, diseases of the nervous system (parkinsonism, small chorea, Little's disease, radiculitis, neuritis, neuralgia). It is also prescribed for Meniere's disease, sea and air sickness. There is evidence of the effectiveness of pyridoxine in patients with atherosclerosis and diabetes mellitus. The therapeutic effect of pyridoxine in depressions of involutional age was also found. The basis for the use of pyridoxine as an antidepressant was his participation as a cofactor of dopa-decarboxylase in the synthesis of catechalamines.

Pyridoxine is also used for acute and chronic hepatitis; however, in severe liver lesions, the administration of high doses of pyridoxine can cause a deterioration in its function.

There is evidence that pyridoxine increases diuresis and enhances the action of diuretics.