Medication Description: Pyridoxine (Pyridoxinum)
VITAMIN B6 (Vitaminum B6).
Synonyms: Adermin, Beadox, Becilan, Bedoxin, Benadon, Besatin, Hexabetalin, Hexabion, Hexavibex, Pyrivitol, etc.
Vitamin B6 activity has a group of compounds, pyridine derivatives, united by the common name "pyridoxine" and differing from each other by substituents in position 4.
A compound with R = CH 2 OH is called pyridoxine, with R = CHO - "pyridoxal", and with R = CH 2 NH 2 - "pyridoxamine".
Pyridoxine hydrochloride (Ruridoxini hydrochloridum) is available for medical use. 2-Methyl-3-hydroxy-4, 5-di- (hydroxymethyl) -pyridine hydrochloride.
White odorless crystalline powder, bitter-sour taste. Easily soluble in water, it is difficult - in alcohol; The pH of a 1% aqueous solution is 2, 5–3, 5. The solutions are sterilized at a temperature of + 100 ° C for 30 minutes. Under the influence of light in aqueous solutions is destroyed.
Vitamin B 6 is found in plants and animal organs, especially in unrefined cereal grains, vegetables, meat, fish, milk, cod liver and cattle, and egg yolk. Relatively high in vitamin B 6 in yeast. The need for vitamin B 6 is satisfied with food; partly it is also synthesized by intestinal microflora.
Pyridoxine plays a large role in metabolism. It is necessary for the normal functioning of the central and peripheral nervous system. Entering the body, it is phosphorylated, turns into pyridoxal-5-phosphate and is part of the enzymes that carry out decarboxylation and transamination of amino acids. Pyridoxine is actively involved in the metabolism of tryptophan, methionine, cysteine, glutamine and other amino acids. It also plays an important role in histamine metabolism.
Pyridoxine is involved in the processes of fat metabolism. Improves lipid metabolism in atherosclerosis.
The daily need for pyridoxine is for adults about 2, 2, 5 mg; for children from 6 months to 1 year - 0.5 mg; from 1 year to 1, 5 years - 0.9 mg; from 1, 5 to 2 years old - 1 mg; from 3 to 4 years - 1, 3 mg; from 5 to 6 years - 1, 4 mg; from 7 to 10 years - 1, 7 mg; 11 to 13 years 2 mg; for boys 14 - 17 years old - 2, 2 mg; for girls 14 - 17 years 1, 9 mg.
Apply pyridoxine in various diseases: In 6 hypovitaminosis, toxicosis of pregnant women; anemia (especially with sideroblastic anemia), leukopenia of various etiologies, diseases of the nervous system (parkinsonism, minor chorea, Little disease, radiculitis, neuritis, neuralgia). It is also prescribed for Meniere's disease, sea and air sickness. There is evidence of the effectiveness of pyridoxine in patients with atherosclerosis and diabetes. The therapeutic effect of pyridoxine was also found in depressions of involutional age. The basis for the use of pyridoxine as an antidepressant agent was its participation as a cofactor of dof-decarboxylase in the process of catechalamine synthesis.
Pyridoxine is also used in acute and chronic hepatitis; however, in severe liver damage, administration of pyridoxine in large doses may cause deterioration of its function.
There is evidence that pyridoxine increases diuresis and enhances the effect of diuretics.