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Description medications: Trypsin (Trypsinum)

Trypsin (Trypsinum).

Endogenous proteolytic enzyme razryvayushy peptide bonds in the protein molecule. Also cleaves high molecular weight decomposition products of proteins, peptones such polypeptides, as well as some low molecular weight peptides containing specific amino acids (arginine, lysine).

Trypsin is a protein with a relative molecular weight of 21 000. Formed in the pancreas of mammals, which contains as an inactive trypsinogen; trypsin last transition is influenced by another enzyme - enterokinase, and formed under the influence of trypsin.

For use in medical practice, trypsin prepared from the pancreas of cattle.

The main drug is crystalline trypsin (Trypsinum srystallisatum). This formulation allowed for both local and parenteral application. Trypsin and amorphous himopsin (a mixture of trypsin chymotrypsin) are permitted only for topical use.

Trypsin, crystalline - a powder white or white with a slightly yellowish white, odorless, or porous mass (after lyophilization). Easily soluble in water and isotonic sodium chloride solution; pH of 0.2% aqueous solution of 3 0 - 5, 5. The solutions are easily destroyed in neutral and alkaline media.

The use of trypsin in the practice of medicine is based on its ability to break down at the local impact of the necrotic tissue and fibrinous formation dilute viscous secrets, exudates, blood clots. The enzyme is active at pH 5, 0 - 8, with the optimum activity of O at pH 7, 0. With respect to the healthy tissues enzyme activity and is safe due to the presence of trypsin inhibitors (specific and nonspecific).

Used as an aid to facilitate the removal of viscous secretions and exudates in inflammatory diseases of the respiratory tract (tracheitis, bronchitis, bronchiectasis, pneumonia, postoperative pulmonary atelectasis, etc.). In these cases, the drug used for inhalation (aerosol), and intramuscularly. Trypsin is thinning mucus and facilitates its isolation. When pleural effusion and pleural empyema trypsin can be administered intrapleural thinners exudate, pus and facilitate their evacuation. When tuberculous empyema should be cautious, given that the absorption of exudate may in some cases contribute to the development of bronchopleural fistula.

In connection with the anti-inflammatory effect is used as crystalline trypsin for intramuscular injections with thrombophlebitis, inflammatory and degenerative forms of periodontal disease, osteomyelitis, sinusitis, otitis and other inflammatory diseases.

The drug reduces edema and should be treated as a single event in the complex therapy of these diseases.