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Description of the medicine: Glutamic acid (Acidum glutaminicum)

GLUTAMINIC ACID (Acidum glutaminicum). 2-Aminoglutaric acid.

Glutamic acid is an essential amino acid. It enters the body with food, but is also synthesized in the body during transamination during protein breakdown. For use as a medicine, obtained synthetically.

Synonyms: Acidogen, Acidulin, Acidum glutamicum, Glutan, Glutansin, etc.

White crystalline powder of sour taste. Slightly soluble in cold water; soluble in hot water; practically insoluble in alcohol. Aqueous solutions (pH 3, 4 - 3, 6) are sterilized at a temperature of + 100 ° C for 30 minutes.

Glutamic acid plays an important role in the life of the body: it participates in protein and carbohydrate metabolism, stimulates oxidative processes, helps neutralize and remove ammonia from the body, and increases the body's resistance to hypoxia. It also contributes to the synthesis of acetylcholine and adenosine triphosphoric acid, the transfer of potassium ions. As part of the protein component, myofibrils play an important role in skeletal muscle activity.

Recently, the central neurotransmitter role of glutamic acid has been given particular importance. It belongs to the neurotransmitter amino acids that stimulate the transmission of excitation in the synapses of the central nervous system.

Endogenous glutamic acid is found in significant quantities in the proteins of the gray and white matter of the brain. When ingested, it is well absorbed, penetrates the blood-brain barrier and cell membranes. Introduced into the body, it is utilized in the process of metabolism; about 4 - 7% is excreted by the kidneys unchanged.

In medical practice, glutamic acid is mainly used in the treatment of central nervous system diseases: epilepsy (mainly small seizures with equivalents), psychosis (somatogenic, intoxication, involutional), reactive states that occur with the effects of exhaustion, depression, etc. In pediatrics, the drug is used for mental retardation of various etiologies, cerebral palsy, Down's disease, polio in the acute and recovery period. Positive results were also noted with the use of glutamic acid (in combination with pachycarpine or glycocol) in patients with progressive myopathy. It is also recommended to prescribe glutamic acid to prevent and relieve neurotoxic phenomena that may occur when using isoniazid and other drugs of the hydrazide group, isonicotinic acid.

Assign inside adults usually 1 g 2 to 3 times a day. Children under the age of 1 year take 0.1 g, up to 2 years - 0.15 g, 3 - 4 years old 0.25 g, 5 - 6 years old - 0.4 g, 7 - 9 years old 0.5 - 1 , 0 g, 10 years and older 1 g (2 to 3 times a day). With oligophrenia, 0.1 to 0.2 g / kg is prescribed for several months.

Accepted 15-30 minutes before meals, and with the development of dyspeptic symptoms - during or after meals. The course of treatment is from 1 to 2 to 6 to 12 months.