Medication Description: Glutamic Acid (Acidum glutaminicum)
GLUTAMINE ACID (Acidum glutaminicum). 2-aminoglutaric acid.
Glutamic acid is a replaceable amino acid. It enters the body with food, but is also synthesized in the body during transamination in the process of protein breakdown. For use as a medicinal product is obtained by synthetic means.
Synonyms: Acidogen, Acidulin, Acidum glutamicum, Glutan, Glutansin, etc.
White crystalline powder of sour taste. Few soluble in cold water; soluble in hot water; practically insoluble in alcohol. Aqueous solutions (pH 3, 4–3, 6) are sterilized at a temperature of + 100 ° C for 30 minutes.
Glutamic acid plays an important role in the vital activity of the organism: it participates in protein and carbohydrate metabolism, stimulates oxidative processes, contributes to the neutralization and elimination of ammonia from the body, increases the body's resistance to hypoxia. It also contributes to the synthesis of acetylcholine and adenosine triphosphate, the transfer of potassium ions. As part of the protein component, myofibrils play an important role in skeletal muscle activity.
Recently, the central neurotransmitter role of glutamic acid has been particularly important. It belongs to the neurotransmitter amino acids that stimulate the transmission of excitation in the synapses of the central nervous system.
Endogenous glutamic acid is found in significant amounts in the proteins of the gray and white matter of the brain. When ingestion is well absorbed, penetrates the blood-brain barrier and cell membranes. Introduced into the body, it is utilized in the process of metabolism; about 4–7% is excreted by the kidneys unchanged.
In medical practice, glutamic acid is used mainly in the treatment of diseases of the central nervous system: epilepsy (mostly minor seizures with equivalents), psychosis (somatogenic, intoxication, involutional), reactive states that occur with signs of exhaustion, depression, etc. In pediatrics, the drug is used for mental retardation of various etiologies, cerebral palsy, Down's disease, polio in the acute and recovery period. Positive results were also noted when glutamic acid was used (in combination with pachicarpine or glycocol) in patients with progressive myopathy. It is also recommended to prescribe glutamic acid to prevent and relieve neurotoxic effects that may occur with the use of isoniazid and other preparations of the hydrazide group, isonicotinic acid.
Assign inside adults usually 1 g 2 - 3 times a day. Children under the age of 1 year old take 0.1 g, up to 2 years - 0.15 g, 3–4 years 0.25 g, 5–6 years - 0.4 g, 7–9 years 0.5 - 1 , 0 g, 10 years and over 1 g (2 - 3 times a day). When oligophrenia is prescribed at 0.1 - 0.2 g / kg for several months.
Take 15 - 30 minutes before a meal, and with the development of dyspeptic phenomena - during or after a meal. The course of treatment from 1 - 2 to 6 - 12 months.