Description medications: Poliglyukin (Polyglucinum)

Polyglukin (Polyglucinum).

6% sterile solution of middle fraction partially hydrolyzed dextran (glucose polymer) in isotonic sodium chloride solution. Prepared by hydrolysis of native dextran synthesized from sucrose involving certain bacteria strain Leuconostoc mesenteroides.

Clear, colorless or slightly yellowish liquid. The average relative molecular mass of 60 000 + 10 000; the relative viscosity of 2, 8, 4, 0; pH 4, 5 - 6 5.

Close on the properties of the drug produced abroad under the title: Dextravan, Ehrandex; Masrodex et al.

Poliglyukin is plazmozameshchath protivoshokovym drug hemodynamic actions. Due to the relatively high relative molecular mass close to that of blood albumin polyglukin slowly penetrates through the vascular wall and, when introduced into the bloodstream, it circulates long. Due to the high osmotic pressure greater than about 2 and 5 times the osmotic pressure of blood plasma proteins, polyglukin retains liquid in the bloodstream, thus providing hemodynamic effects.

Poliglyukin quickly raises blood pressure in acute blood loss and keeps it for a long time at a high level. The drug is nontoxic, distinguished mainly by the kidneys (approximately 50% in the first day). A small amount is deposited in the reticuloendothelial system, where it is gradually broken down to glucose. The drug is not, however, a source of carbohydrate food.

Apply polyglukin prophylactic and therapeutic purposes in traumatic, surgical and burn shock, acute hemorrhage, shock resulting from intoxications, sepsis, and others.

The drug is administered intravenously, and acute blood loss and intra. The speed of the general state of the patient, level of blood pressure, heart rate, hematocrit.

When razvivshemsya shock polyglukin administered intravenously, typically use 400 to 1,200 ml per infusion (if necessary to 2000 ml). If blood pressure rises to a level close to normal, moving to a drip. With more than 500 ml blood loss and severe anemizatsii patient, combined with the introduction of polyglucin blood transfusion.

In order to prevent shock during operations polyglukin introducing drip; in the case of blood pressure drop pass to the bolus. In sharp reduced pressure (below 60 mm Hg. V.) Suitable intraarterial preparation (400 ml). Postoperatively, jet-drip polyglucin is an effective way to prevent posleoperatsnonnogo shock. Children prescribed rate of 10 - 15 ml per 1 kg of body weight.

For the treatment of burn shock is administered within 24 hours to 2000 - 3000 ml of the preparation and in the following 24 hours - to 1500 ml. Children in the first 24 hours administered by 40 - 50 ml per 1 kg of body weight per day in the following - 30 ml / kg.