Description of the medicine: Chloridine (Chloridinum)

Chloridinum. 2, 4-Diamino-5-p-chlorophenyl-6-ethyl-pyrimidine. Synonyms: Daraprim, Pyrimethamine, Tindurine, Daraclor, Darapran, Daraprim, Malocide, Pyrimethamine, Tindurin.

White crystalline powder odorless and tasteless. Almost nerastvorim in water, little soluble in alcohol.

The drug has an antiprotozoal effect, is effective against plasmodia of malaria, toxoplasm and leishmania.

It suppresses the development of asexual erythrocyte forms of all species of plasmodia, but acts more slowly than hingamin. Causes damage to the gametes of all kinds of plasmodia, which leads to a disruption in the development of malaria pathogens in the mosquito. The mechanism of action is associated with the inhibition of the enzyme dihydrofolate reductase, which blocks the conversion of dehydrofolic acid to tetrahydrofolic, necessary for the development of parasitic microorganisms.

With leishmaniasis, chloridine damages promastigoty (flagellar leishmania stages), which leads to a disruption of the development of leishmaniasis in the mosquito.

Chlorilin is well absorbed, circulates for a long time in the blood (within 1 week after a single dose); Is excreted mainly by the kidneys.

Take chloride inside simultaneously with sulfonamides or (and) hingaminom, while the effectiveness of chloride significantly increases.

Assign chloridine to adults in a daily dose of 0.05 g, for the prevention of diseases - to 0.025 grams in 1 to 3 doses.

Children are given in smaller doses according to age.

In acute forms of malaria take the drug for 2 - 4 days. For the prevention of malaria and leishmaniasis, prescribe for 3 to 5 days before the onset of the risk of infection and continue to give 1 time per week for the entire period of possible infection and for another 4 to 6 weeks.

With acute and chronic toxoplasmosis, chloride is taken by cycles for 5 days with a break between them 7-10 days. The course of treatment is 2 - 3 cycles. If necessary, courses (3 total) are repeated with an interval of 1 to 2 months.

For the prevention of congenital toxoplasmosis, chloridine is prescribed for women with acute and subacute toxoplasmosis, starting from the 16th week of pregnancy, but not earlier than the second trimester. The course of treatment is 2 cycles with an interval of 10 days. Depending on the duration of pregnancy, up to 3 courses are conducted with a break between them for 1 month.

At an earlier time of pregnancy, chloridine should not be given (to avoid toxic effects on the fetus), and later should also be given with caution.

Sulfanilamide preparations (see Sulfapyridazine, Sulfadimethoxin, Sulfalen) are administered simultaneously with chloridine.

When taking chloridine, there may be side effects: headache, dizziness, pain in the heart, dyspepsia, stomatitis, retinopathy, alopecia.

Due to the fact that chloride is an antagonist of folic acid, its long-term use can cause side effects associated with a violation of the assimilation and exchange of this vitamin.