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Description of the medicine: Trazodon (Trazodonum)

TRAZODON (Trazodonum) *. 2- {3- [4- (3-Chlorophenyl) -1-piperazinyl] propyl} 1, 2, 4-triazolo- [4, 3-a] - pyridin-3- (2H) -OH.

Synonyms: Azona, Beneficat, Bimaran, Desyrel, Geripax, Menegan, Molipaxin, Pragmarel, Pragmazine, Sideril, Thombran, Tramensan, Trazolan, Trazone, Tresin, Trittico.

The drug has an antidepressant (timoleptic) effect, combined with anxiolytic and tranquilizing effect. In pharmacological properties and neurochemical action it differs from typical antidepressants; does not reduce the depressive effect of reserpine, weakens the central effects of phenamine and the peripheral effect of norepinephrine; does not significantly affect neuronal uptake of catecholamines, but selectively blocks uptake of serotonin.

They are used for various forms of depression (endogenous, psychotic, neurotic, somatogenic, etc.) with anxiety, tension.

Due to its good tolerance by the absence of anticholinergic action, trazodone is widely used in the treatment of elderly patients with organic diseases of the central nervous system, as well as in the complex treatment of patients with somatic diseases complicated by mental disorders (anxiety, tension, etc.).

Assign inside, sometimes intramuscularly and into a vein. The initial dose for oral administration is 50 mg 3 times a day, then, depending on the type and severity of depression, up to 300 - 500 mg per day. The therapeutic effect is usually observed after 3 to 7 days from the start of treatment.

When used as an anxiolytic agent (for neurotic and somatic depressions), 25 mg 3 times a day is prescribed.

50 mg are administered into a vein and intramuscularly as an anxiolytic agent for sedation before surgery.

Side effects: fatigue, drowsiness, headache, dizziness, insomnia, lowering blood pressure - are relatively rare and disappear with a decrease in dose. The drug should not be prescribed simultaneously with MAO inhibitors.

Method of release: capsules containing 25; 50 or 100 mg of the drug; 1% solution in ampoules of 5 ml (50 mg in ampoule).