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Medication Description: Ampicillin (Ampicillinum)

Ampicillin (Ampicillinum). 6- [D (-) - a-Aminophenylacetamido] -penicillanic acid.

Synonyms: Pentrexil, Abetathen Domicillin, Domipen, Eurocillin, Fortapen, Grampenil, Isticilline, Lificil1in, Maxibiotic, Maxipred, Morepen, Negopen, Opicilin, Oracilina, Penberin, Penbrock, Penibrin, Pentrex, Pentrexil, Pentrexyl, Poligilin, and in-your-rest, in-your-your own account, and in the form of a fight, in your own words, and in your project. Totacillin, Ultrabion, Vampen, Vexampil, Vidopen, Zymopen, etc.

Crystalline powder of white color, bitter in taste; stable in an acidic environment. It is soluble in water, practically insoluble in alcohol.

Ampicillin is a semi-synthetic antibiotic obtained by acylation of 6-aminopenicillanic acid with an aminophenylacetic acid residue.

The drug is not destroyed in the acidic environment of the stomach, is well absorbed by ingestion. Active against gram-positive microorganisms that are affected by benzylpenicillin. In addition, it acts on a number of gram-negative microorganisms [Salmonella, Shigella, Proteus, E. coli, Klebsiella pneumonia (Friedlander wand), Pfeiffer wand (Influenza wand)] and therefore is considered as a broad-spectrum antibiotic and is used for diseases caused by mixed infection.

Penicillin-forming staphylococci resistant to benzylpenicillin, ampicillin does not work, since it is destroyed by penicillinase.

Ampicillin is used to treat patients with pneumonia, bronchopneumonia, with lung abscesses, sore throat, peritonitis, cholecystitis, sepsis, intestinal infections, with postoperative soft tissue infections and with other infections caused by susceptible microorganisms.

The drug is highly effective in urinary tract infections caused by Escherichia coli, Proteus, enterococci, or a mixed infection, as it is excreted unchanged with urine in high concentrations. Ampicillin is also supplied in large quantities to the bile. The drug is effective in treating gonorrhea.

Assign ampicillin inside (regardless of the meal). Single dose for adults is 0.5 g, daily 2 - 3 g. Children are prescribed at the rate of 100 mg / kg. The daily dose is divided into 4 - 6 receptions.

The duration of treatment depends on the severity of the disease and the effectiveness of therapy (from 5 to 10 days to 2 to 3 weeks or more).

When treating with ampicillin, allergic reactions may occur in the form of skin rash, urticaria, angioedema, etc., in rare cases - anaphylactic shock (mainly with the administration of ampicillin sodium salt).

In the event of an allergic reaction, it is necessary to stop the administration of the drug and conduct desensitization therapy. If signs of anaphylactic shock appear, urgent measures should be taken to remove the patient from this condition.

With prolonged treatment with ampicillin, in debilitated patients, the development of superinfection caused by drug-resistant microorganisms (yeast-like fungi, gram-negative microorganisms) is possible. It is advisable for these patients to simultaneously prescribe vitamins of group B and vitamin C, and if necessary, nystatin or levorin.