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Description medications: Ampicillin (Ampicillinum)

Ampicillin (Ampicillinum). 6- [D (-) - a aminophenylacetamido] -penitsillanovaya acid.

Synonyms: Pentreksil, Abetathen, Acidocycline, Acilin, Acrocilin , Agnopen, Albercilin, Amcil, Amecillin, Ampen, Ampexin, Ampifen, Ampilin, Ampiopenil, Amplenil, Amplital, Bactipen, Biampen, Binotal, Britapen, Broadocilin, Cimexillin, Diaciclin, Dicillin, Domicillin, Domipen, Eurocillin, Fortapen, Grampenil, Isticilline, Lificil1in, Maxibiotic, Maxipred, Morepen, Negopen, Opicilin, Oracilina, Penberin, Penbrock, Penibrin, Pentrex, Pentrexil, Pentrexyl, Policilin, Riomycin, Roscillin, Semicillin, Sintelin, Synpenin, Totacillin, Ultrabion, Vampen, Vexampil, Vidopen, Zymopen and others.

Crystalline powder of white color, bitter taste; stable in an acidic environment. It is soluble in water, practically insoluble in alcohol.

Ampicillin - semi-synthetic antibiotic obtained by acylation of 6-aminopenicillanic acid residue aminophenylacetic acid.

The drug is not destroyed in the acidic environment of the stomach, is well absorbed when taken orally. It is active against gram-positive organisms, which operates benzylpenicillin. In addition, it operates a number of Gram-negative organisms [Salmonella, Shigella, Proteus, E. coli, Klebsiella pneumonia (bacillus Friedlander), bacillus Pfeiffer (influenza bacillus)] and is therefore seen as a broad-spectrum antibiotic and is used in diseases caused by mixed infection.

On penitsillinazoobrazuyuschie staphylococci resistant to benzylpenicillin, ampicillin is not valid, since destroyed by penicillinase.

Apply ampicillin for treatment of pneumonia, bronchopneumonia, lung abscesses, angina, peritonitis, cholecystitis, sepsis, intestinal infections, postoperative soft tissue infections and other infections caused by microorganisms sensitive to it.

The drug is highly effective in urinary tract infections caused by Escherichia coli, Proteus, enterococci, or mixed infection, as it is excreted unchanged in the urine in high concentrations. In large quantities ampicillin also fed into bile. The drug is effective in the treatment of gonorrhea.

Assign inside ampicillin (regardless of the meal). Single dose for adults is 0.5 grams daily 2 - 3 years Children appoint a rate of 100 mg / kg. The daily dose is divided into 4 - 6 receptions.

The duration of treatment depends on the severity of the disease and the effectiveness of therapy (5 - 10 days to 2 - 3 weeks or more).

When treating ampicillin could experience allergic reactions such as skin rash, urticaria, angioedema, and others, in rare cases -. Anaphylactic shock (mainly the introduction of the sodium salt of ampicillin).

In the case of occurrence of allergic reactions should stop administering the drug and conduct desensitizing therapy. If signs of anaphylactic shock, urgent measures should be taken to remove the patient from the condition.

Prolonged treatment with ampicillin, in debilitated patients may develop superinfection caused by resistant to malaria infections (yeast-like fungi, Gram-negative organisms). These patients expedient to appoint a group of B vitamins and vitamin C, if necessary - or Nystatin Levorinum.