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Description of the medicine: Sodium para-aminosalicylate (Natrii para-aminosalicylas)

SODIUM PART-AMINOSALICYLATE (Natrii para-aminosalicylas). 4-Amino-2-hydroxy-benzoate sodium, or the sodium salt of para-aminosalicylic acid.

Synonyms: PASK-sodium, Aminacyl, Aminopar, Aminosalyl, Aminox, Apacil, Bactylan, Eupasal, Natrium para-aminosalicylicum, Pamisyl, Paramisan, Para-Pas, Parasal, Pasalicylum solubile, Propasa, Tebaminal, Teebacin, Tubopas, Wofapas and others.

White or white with a slightly yellowish or slightly pinkish tinge fine crystalline powder. Easily soluble in water, hard - in alcohol. Para-aminosalicylic acid and its sodium salt (abbreviated PASC) have bacteriostatic activity against mycobacteria tuberculosis and are among the main antituberculosis drugs.

When ingestion, PASK is well absorbed and penetrates into the serum and tissues of the internal organs.

According to tuberculostatic activity, PASC is inferior to isoniazid and streptomycin, therefore it is combined with other, more active, anti-tuberculosis drugs (isoniazid or other preparations of isonicotinic acid hydrazide, cycloserine, kanamycin, etc.). Combination therapy slows the development of drug resistance and enhances the action of the corresponding drugs.

PASK in combination with other drugs is effective in various forms and localizations of tuberculosis.

Assign PASK inwards in the form of powder, tablets (pellets) or granules to adults 9-12 grams per day (3-4 grams 3 times a day), children - 0.2 g / kg per day in 3 to 4 doses (daily Dose not more than 10 g). Take 1/2 - 1 hour after meals, washed down with milk, alkaline mineral water, 0.5 - 2% solution of sodium hydrogen carbonate.

Exhausted adult patients (with a body weight less than 50 kg), as well as with poor tolerance, the drug is given in a dose of 6 g per day.

In outpatient practice, you can appoint a daily dose of 1 reception, but with poor tolerability, the daily dose is divided into 2 to 3 doses.

Sodium para-aminosalicylate for oral administration is used in the following dosage forms: a) powder; B) tablets (white or white with a pinkish or yellowish tinge); C) tablets, soluble in the intestine (orange-red color); D) coated tablets (light lilac or light lilac with a pinkish tinge); E) granules (from light yellow to greenish-yellow) containing 1 part of sodium para-aminosalicylate and 2 parts of sugar; E) solution for injection. Granules are better tolerated than pure PASK. One teaspoon holds 6 g of granules, which corresponds to 2 g of sodium para-aminosalicylate and 4 g of sugar. Taking 1 or 2 teaspoons 3 times a day, the patient receives 6 or 12 grams of sodium-para-aminosalicylate.

When using PASC, there may be side effects. The most frequently observed gastrointestinal disorders: deterioration (or loss) of appetite, nausea, vomiting, abdominal pain, diarrhea or constipation. These phenomena usually decrease with a reduced dose or a short-term break in treatment, they are less pronounced with the correct (regular three meals a day) diet, and sometimes when taking the drug in the form of granules.