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Description medications: corazole (Corazolum)
Korazol (Corazolum) 1, 5 Pentametilentetrazol.
Synonyms: Angiazol, Cardiazol, Centrazol, Deumacar , Diovascol, Leptazol, Metrazol, Pentamethazolum, Pentazol, Pentetrazolum, Pentrazol, Pentylentetrazol, Phrenazole, Tetracor and others.
The white crystalline powder. Very easily soluble in water and alcohol. Aqueous solutions (pH 6, 0 - 8, 0) + sterilized at 100 C for 30 min.
It has a stimulating effect on the respiratory and vasomotor centers. Initiation of breathing, increased blood pressure and improving blood circulation particularly pronounced if the centers of the medulla oblongata are depressed. Direct impact on the heart and blood vessels the drug does not render.
In large doses, it causes the brain and spinal cord stimulation and can provide a wake-up << >> effect in acute poisoning by drugs and narcotics. In large doses korazol also has a convulsive action related mainly to the influence of the motor areas of the brain, and only partially - with the effect on the spinal cord.
Last korazol widely used in shock, asphyxiation, weakening of cardiac activity during surgical procedures, as well as the poisoning of drugs, hypnotics, analgesics.
In psychiatric practice Corazol used for seizure treatment of schizophrenia.
Recently, the use of Corazol (and other analeptikov) for poisoning hypnotics began to consider impractical, as this increases the brain's need for oxygen. In addition, more specific means for poisoning by barbiturates and other means to narcosis is Bemegride (cm.). When poisoning narcotic analgesics began to use a specific antagonist - naloxone (see.).
In psychiatric practice currently korazol also does not apply.
Therefore korazol excluded from the range of medicines.
However korazol remains a valuable tool for the experimental pharmacological studies. They are widely used in the search and study of anticonvulsants and other neuro (psycho) tropic drugs.
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