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Description of the medicine: Lobelin (Lobelinum)

LOBELIN (Lobelinum).

The alkaloid contained in the plant Lobelia inflata, fam. bell-shaped (Campanulaceae). Optically active. Lobelin racemate is synthetically prepared.

In medical practice, lobelin hydrochloride (Lobelini hydrochloridum) is used.

l-1-Methyl-2-benzoylmethyl-6- (2-hydroxy-2-phenylethyl) piperidine hydrochloride.

Synonyms: Lobesil, Antisol, Atmulatin, Bantron, Lobatox, Lobeline, Lobelinum hydrochloricum, Lobesilum, Lobeton, Lobidan, etc.

White crystalline powder of bitter taste, odorless. It is soluble in water (1: 100), soluble in alcohol (1:10).

It has a specific stimulating effect on the ganglia of the autonomic nervous system and carotid glomeruli (see also Ganglioblocking drugs), which is accompanied by excitation of the respiratory and other centers of the medulla oblongata.

Exciting the vagus nerve at the same time, lobelin causes a slowdown in heartbeats and a decrease in blood pressure. Later, blood pressure may increase slightly due to narrowing of blood vessels, due to the stimulating effect of the drug on the sympathetic ganglia and adrenal glands. In large doses, lobelin excites the vomiting center, causes deep respiratory depression, tonic-clonic convulsions, cardiac arrest.

In connection with the ability to stimulate respiration, lobelin was proposed as an analeptic agent for use in reflex respiratory arrests (mainly when inhaling irritating substances, carbon monoxide poisoning, etc.).

Recently, as a respiratory stimulant, it has been used extremely rarely. When weakening or stopping breathing, developing as a result of progressive depletion of the respiratory center, the introduction of lobelin is not shown.

Apply intravenously, less intramuscularly.

Adults are administered at 0.003-0.005 g (0.3-0.5 ml of a 1% solution), children, depending on age, at 0.001-0.003 g (0.1-0.3 ml of a 1% solution). Intravenous administration is more effective.

Lobelin is administered intravenously slowly (1 ml for 1-2 minutes). With rapid administration, temporary respiratory arrest (apnea) sometimes occurs and side effects from the cardiovascular system (bradycardia, conduction disturbance) develop.

Maximum doses for adults: in a vein - single 0.005 g, daily 0.01 g; in muscles - a single 0.01 g daily 0.02 g.

The drug is contraindicated in severe organic diseases of the cardiovascular system.

Lobelin and other gangliostimulating substances similar to it (cytisine, anabazine) have been used in recent years as auxiliary agents for smoking cessation.

Tablets containing 0.002 g (2 mg) of lobelin hydrochloride are available for this purpose under the name "Lobesil" (Tabulettae "Lobesilum"). They are covered with a membrane (cellulose acetate), which ensures the passage of the drug unchanged through the stomach and its rapid release in the intestine.

After stopping smoking, take 1 tablet orally 4-5 times a day for 7-10 days.