Description medications: Lobeline (Lobelinum)

Lobeline (Lobelinum).

Alkaloid contained in the plant Lobelia inflata, Sem. Campanulaceae (Campanulaceae). Optically active. lobelina racemate obtained synthetically.

In medical practice using lobeline hydrochloride (Lobelini hydrochloridum).

l-1-methyl-2-benzoylmethyl-6- (2-hydroxy-2-phenylethyl) piperidine hydrochloride.

Synonyms: Lobesil, Antisol, Atmulatin, Bantron, Lobatox , Lobeline, Lobelinum hydrochloricum, Lobesilum, Lobeton, Lobidan and others.

The white crystalline powder bitter taste, and odorless. It is soluble in water (1: 100), soluble in alcohol (1:10).

It provides specific stimulating effect on the autonomic ganglia of the nervous system and carotid glomeruli (see. Also ganglioblokiruyuschimi drugs), which is accompanied by the excitation of respiratory and other centers of the medulla oblongata.

Exciting at the same time the vagus nerve, lobeline causes slowing heart rate and lowering blood pressure. Later, blood pressure may rise somewhat by narrowing the blood vessels caused by the stimulating effect of the drug on the sympathetic ganglia and adrenal glands. In large doses, lobeline excites the vomiting center, causing a profound respiratory depression, tonic-clonic seizures, cardiac arrest.

In connection with the ability to initiate breathing lobeline has been proposed as analeptic agents for use in the reflex breathing stops (mainly inhaled irritants, carbon monoxide poisoning, etc.).

Recently, as a respiratory stimulant is rarely used. When loosening or respiratory arrest, developing as a result of the progressive exhaustion of the respiratory center, the introduction of lobeline is not shown.

Applied intravenously, intramuscularly less.

Adults are injected at 0,003-0,005 g (0.3-0.5 mL of 1% solution) for children according to the age at 0.001-0.003 g (0.1-0.3 mL of 1% solution). Intravenous administration more efficiently.

Lobeline slowly intravenously injected (1 ml over 1-2 min). With the rapid introduction sometimes occurs a temporary cessation of breathing (apnea) and develop side effects to the cardiovascular system (bradycardia, conduction abnormalities).

The maximum dose for adults: a vein - single 0,005 grams daily 0.01 g; in muscles - single 0.01 grams daily 0.02 g

The drug is contraindicated in severe organic diseases of the cardiovascular system.

Lobeline and others similar to it by the action gangliostimuliruyuschie substance (cytisine, anabasine) have found use in recent years as an aid in smoking cessation.

Tablets containing 0.002 g (2 mg) lobeline hydrochloride, available for this purpose, called "Lobesil» (Tabulettae «Lobesilum»). They coated (acetylphthalyl) allowing the passage of drug through the stomach unaltered and its rapid release in the intestine.

After smoking cessation is taken orally 1 tablet 4-5 times a day for 7-10 days.