Medication Description: Lobelin (Lobelinum)
Alkaloid contained in the plant Lobelia inflata, herewith. Campanulaceae (Campanulaceae). Optically active. The racemate lobeline is obtained by synthetic means.
In medical practice, lobeline hydrochloride (Lobelini hydrochloridum) is used.
l-1-methyl-2-benzoylmethyl-6- (2-hydroxy-2-phenylethyl) -piperidine hydrochloride.
Synonyms: Lobesil, Antisol, Atmulatin, Bantron, Lobatox, Lobeline, Lobelinum hydrochloricum, Lobesilum, Lobeton, Lobidan, etc.
White crystalline powder bitter taste, odorless. It is soluble in water (1: 100), soluble in alcohol (1:10).
It has a specific stimulating effect on the ganglia of the autonomic nervous system and carotid glomeruli (see also Ganglioblokiruyuschie drugs), which is accompanied by the initiation of the respiratory and other centers of the medulla oblongata.
Exciting at the same time the vagus nerve, Lobelin causes a slower heartbeat and a decrease in blood pressure. Later, blood pressure may increase slightly due to vasoconstriction due to the stimulating effect of the drug on the sympathetic ganglia and the adrenal glands. In large doses, lobelin stimulates the vomiting center, causes deep respiratory depression, tonic-clonic convulsions, cardiac arrest.
In connection with the ability to initiate respiration, lobelin was proposed as an analeptic for use in reflex respiratory arrest (mainly by inhalation of irritants, carbon monoxide poisoning, etc.).
Recently, as a respiratory stimulator, it is used extremely rarely. When easing or stopping breathing, developing as a result of progressive depletion of the respiratory center, the introduction of Lobeline is not shown.
Used intravenously, less intramuscularly.
Adults are administered in 0.003-0.005 g (0.3-0.5 ml of 1% solution), children, depending on their age, in 0.001-0.003 g (0.1-0.3 ml of 1% solution). Intravenous administration is more effective.
Intravenous lobelin is administered slowly (1 ml for 1-2 minutes). With the rapid introduction sometimes comes a temporary cessation of breathing (apnea) and side effects from the cardiovascular system (bradycardia, impaired conductivity) develop.
Maximum doses for adults: in a vein - single 0.005 g, daily 0.01 g; in muscles - single 0.01 g, daily 0.02 g
The drug is contraindicated in marked organic diseases of the cardiovascular system.
Lobelin and other ganglion-stimulating substances similar to it in action (cytisine, anabasin) have been used in recent years as an aid in disaccustoming.
Tablets containing 0.002 g (2 mg) of lobeline hydrochloride are produced for this purpose under the name "Lobesil" (Tabulettae "Lobesilum"). They are coated (acetylphthalyl cellulose), ensuring the passage of the drug in unchanged form through the stomach and its rapid release in the intestine.
After smoking cessation, take orally 1 tablet 4-5 times a day for 7-10 days.