Description of the medicine: Embichin (Embichinum)
Methyl bis- (b-chloroethyl) -amine hydrochloride.
Synonyms: Mustargen, Caryolysine, Chlorethazine, Chlormethine, Dichloren, Dimitan, Duamin, Erasin HN2, Mechlorethamine hydrochloride, Metichloramine, Mustargen, Mustine, Nitrogranulogen, N-Yperit, Stickstoflost, etc.
White crystalline powder, soluble in water. Solutions (on isotonic sodium chloride solution) are prepared (due to their instability) ex tempore.
The drug is active in chronic myelosis, lympho- and reticulosarcoma, lymphogranulomatosis, fungoid mycosis, and small cell lung cancer.
Currently, it is used mainly in the treatment of lymphogranulomatosis in the complex therapy system.
Embiquin is administered intravenously. When the “shock” technique is administered for 4 days in a total dose of 0.4 mg / kg (0.1 mg / kg per day) or 0.4 mg / kg once. Sometimes they use the <fractional> technique: the drug is administered in a dose of 5-6 mg 3 times a week; the total dose (for 8 to 20 administrations) is 40 to 120 mg.
Treatment is stopped with a decrease in the white blood cell count to 2, 5 3 x 10 9 / L.
Embihin can also be introduced into serous cavities (0.2 mg / kg in 10-50 ml of isotonic sodium chloride solution) in the presence of effusion containing tumor cells.
Treatment with embihin should be carried out under close medical supervision. When using the drug, complications and side effects may occur associated with its local irritating properties and general toxic effects, especially the effect on hematopoiesis.
With intravenous administration of embihin, care should be taken to ensure that the solution does not get under the skin, since the appearance of infiltrate and tissue necrosis is possible. If the solution enters the subcutaneous fat, immediately inject some isotonic sodium chloride solution into this place. When an infiltrate occurs, compresses are used.
You should beware of getting solutions of the drug on the mucous membranes and skin of the patient and medical personnel. If this happens, immediately rinse thoroughly with water.
To prevent the development of phlebitis in patients (especially with repeated injections), it is advisable to inject an additional 20 ml of warm Ringer's solution into the vein after the injection and not pinch the vein at the injection site after the injection.
Some patients experience nausea and headache within 1-3 hours after drug administration, sometimes vomiting occurs. To attenuate or eliminate vomiting, chlorpromazine (0.025 g orally or intramuscularly 1 hour after embichin injection) or etaperazine are prescribed. You can also enter embihin in the evening (after dinner), and prescribe sleeping pills at night.
In the process of treatment with embihin, it is necessary to monitor changes in the blood picture. A serious complication in case of an overdose of the drug can be deep inhibition of bone marrow function with a sharp suppression of hematopoiesis, up to the phenomena of aplasia of the hematopoietic tissue (with a fatal outcome).
In the treatment with fractional doses of embihin, the effect on leuko- and thrombopitopoiesis is less pronounced.
Storage: List A.