Medication Description: Embichinum (Embichinum)
Methyl bis- (b-chloroethyl) -amine hydrochloride.
Synonyms: Mustargen, Caryolysine, Chlorethazine, Chlormethine, Dichloren, Dimitan, Duamin, Erasin HN2, Mechlorethamine hydrochloride, Metichloramine, Mustargen, Mustine, Nitrogranulogen, N-Yperit, Stickstoflost, etc.
White crystalline powder, soluble in water. Solutions (on an isotonic solution of sodium chloride) are prepared (due to their instability) ex tempore.
The drug is active in chronic myelosis, lymphoid and reticulosarcoma, lymphogranulomatosis, fungal mycosis, small cell lung cancer.
Currently, it is used mainly in the treatment of Hodgkin's disease in the system of complex therapy.
Embikhin is administered intravenously. With the <shock> method, a total dose of 0.4 mg / kg (0.1 mg / kg per day) or 0.4 mg / kg is administered once a day for 4 days. Sometimes they use the fractional method: the drug is administered in a dose of 5-6 mg 3 times a week; The total dose (for 8–20 administrations) is 40–120 mg.
Treatment is stopped by reducing the content of leukocytes in the blood to 2, 5 3 x 10 9 / l.
Embiquine can also be injected into serous cavities (0.2 mg / kg in 10-50 ml of isotonic sodium chloride solution) if there is an effusion in them containing tumor cells.
Treatment with embiquine should be carried out under close medical supervision. When using the drug, there may be complications and side effects associated with its local irritant properties and general toxic effects, especially the effect on hematopoiesis.
In case of intravenous administration of embiquine, care should be taken to ensure that the solution does not get under the skin, since infiltration and tissue necrosis may occur. If the solution gets into the subcutaneous fatty tissue, it is necessary to immediately introduce a certain amount of isotonic sodium chloride solution into this place. In the event of infiltration apply compresses.
It is necessary to be careful not to get the drug solutions on the mucous membranes and skin of the patient and medical personnel. If this happens, you should immediately wash the drug thoroughly with water.
To prevent the development of phlebitis in patients (especially with repeated injections), it is advisable to inject an additional 20 ml of Ringer's warm solution into the vein after the injection and not pinch the vein at the injection site after the injection.
In some patients, 1 to 3 hours after administration of the drug, nausea and headache occur, sometimes vomiting. To reduce or eliminate vomiting prescribed aminazin (0.025 g orally or intramuscularly 1 h after injection of embiquine) or eporazine. You can also enter embikhin in the evening (after dinner), and appoint sleeping pills for the night.
In the process of treatment with embiquine, it is necessary to monitor changes in the blood picture. A serious complication of an overdose of the drug can be a deep inhibition of bone marrow function with a sharp suppression of hemopoiesis, up to the phenomena of hematopoietic aplasia (fatal).
In the treatment of fractional doses of embiquine, the effect on leuko- and thrombopitopoiesis is less pronounced.
Storage: List A.