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Description of the medicine: Nitrazepam (Nitrazepamum)

NITRAZEPAM (Nitrazepamum). 7-Nitro-2, 3-dihydro-5-phenyl-1H-1, 4-benzodiazepin-2-one:

Synonyms: Mogadon, Neozepam, Radedorm, Eunoktin, Apodorm, Benzalin, Calsmin, Dormicum, Dumolid, Epibenzalin, Epinelbon, Eunoctin, Hipnax, Hipsal, Insomin, Livetan, Magadon, Mitidin, Mogadan, Mogadon, Nelpam, Nelpam, Nelpam, Nelpam Pacidrim, Pacisyn, Radedorm, Serenex, Somitran, Sonipam, Sonnolin, etc.

Light yellow or light yellow with a greenish tint crystalline powder. It is practically insoluble in water, slightly soluble in alcohol and ether.

In chemical structure and pharmacological properties, nitrazepam is close to the tranquilizers of the benzodiazepine group (see) A distinctive structural feature of nitrazepam is the presence of a nitro group (NO) at position 7 of the benzodiazepine core.

Like other derivatives of benzodiapesin, nitrazepam has a tranquilizing, anxiolytic (anti-anxiety), muscle relaxant (muscle-relaxing), anticonvulsant effect, inhibits conditioned reflexes, and suppresses polysynaptic spinal reflexes. A distinctive feature of nitrazepam is its pronounced hypnotic effect.

Under the influence of nitrazepam, the depth and duration of sleep increase. Sleep usually occurs after 45 minutes. after taking the drug and lasts 6-8 hours.

Nitrazepam is used for sleep disorders of various nature, as well as for neuroses of various origins and psychopathies with a predominance of anxiety. In combination with other psychotropic drugs, the drug is prescribed for patients with schizophrenia, manic-depressive psychosis (in the manic and hypomanic phases), with some organic lesions of the central nervous system (trauma of cerebrovascular accident), as well as for relief of withdrawal symptoms in chronic alcoholism.

As a sedative and anticonvulsant, nitrazepam in combination with anticonvulsants is prescribed for patients with epilepsy. The drug is also used in anesthetic practice for sedation and in the postoperative period.

Take nitrazepam orally; as a sleeping pill - for half an hour and sleep. A single dose for adults is 0.005-0.01 g (5-10 mg); for children under the age of 1 year 0.00125 - 0.0025 g (1, 25-2.5 mg), 1 - 5 years old 0025 - 0.005 g (2.5-5 mg); 6-14 years old - 0.005 g (5 mg). Elderly people are prescribed at 0.0025 - 0.005 g (2, 5 - 5 mg). The maximum single dose as a sleeping pill for adults is 0.02 g (20 mg). As a tranquilizer and anticonvulsant, nitrazepam is used 2-3 times a day at 0.005-0.01 g (5-10 mg); if necessary, a single dose of the drug as an anticonvulsant can be increased. The highest daily dose of 0.03 g (30 mg). With a course of treatment, the duration of use of nitrazepam is 30 - 45 days. In some cases, the duration of treatment may be increased.

When using nitrazepam, especially in large doses, daytime drowsiness, a feeling of lethargy, ataxia, impaired coordination of movements, headache, stupor, dizziness are possible, in rare cases nausea, tachycardia, hyperhidrosis, and skin-allergic reactions occur.