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Description of the medicine: Nitrazepam (Nitrazepamum)

NITRAZEPAM (Nitrazepamum). 7-Nitro-2, 3-dihydro-5-phenyl-1H-1, 4-benzodiazepin-2-one:

Synonyms: Mogadon, Neozepam, radedorm, Eunoktin, Apodorm, Benzalin, Calsmin, Dormicum , Dumolid, Epibenzalin, Epinelbon, Eunoctin, Hipnax, Hipsal, Insomin, Livetan, Magadon, Mitidin, Mogadan, Mogadon, Nelbon, Neozepam, Nitrenpax, Nitrodiazepam, Pacidrim, Pacisyn, Radedorm, Serenex, Somitran, Sonipam, Sonnolin and others.

Light yellow or light yellow with a greenish tinge crystalline powder. Almost nerastvorim in water, sparingly soluble in alcohol and ether.

On chemical structure and pharmacological properties similar to nitrazepam tranquilizer benzodiazepine group (See.) The distinctive feature of stukturnoy nitrazepama is the presence of the nitro group (NO) in the 7-position of the benzodiazepine nucleus.

Like other derivatives benzodiapezina, nitrazepam has tranquilizing, anxiolytic (antianxiety), muscle relaxant (muscle-relaxing), an anticonvulsant effect, depresses conditioned reflexes, suppresses polisinapticheskie spinal reflexes. A distinctive feature of nitrazepam is its pronounced hypnotic effect.

Under the influence of nitrazepam, the depth and duration of sleep increases. Sleep usually comes in 45 minutes. After taking the drug and lasts 6-8 hours.

Apply nitrazepam with sleep disorders of various kinds, as well as in the neuroses of different genesis and psychopaths with a predominance of anxiety. In combination with other psychotropic drug agents prescribed to patients with schizophrenia, manic-depressive psychosis (in manic and hypomanic phases), when certain organic lesions of the central nervous system (trauma disorders of cerebral circulation), as well as for the relief of withdrawal symptoms in chronic alcoholism.

As a soothing and anticonvulsant, nitrazepam, in combination with anticonvulsants, is prescribed to patients with epilepsy. The drug is also used in anesthesia practice for premedication and in the postoperative period.

Take nitrazepam inside; As a sleeping pill - for half an hour and sleep. A single dose for adults is 0.005-0.01 g (5-10 mg); for children under 1 year of 0.00125 - 0.0025 g (1, 2 25, 5 mg), 1 - 5 years 0025 - 0.005 g (2, 5 - 5 mg); 6 - 14 years - 0,005 g (5 mg). The elderly are prescribed 0.0025-0.005 g (2.5-5 mg). The maximum single dose as a sleeping pills for adults is 0.02 g (20 mg). As a tranquilizer and an anticonvulsant, nitrazepam is used 2-3 times a day for 0.005-0.01 g (5-10 mg); If necessary, a single dose of the drug as an anticonvulsant can be increased. The highest daily dose of 0.03 g (30 mg). At course treatment duration of nitrazepam application is 30 - 45 days. In some cases, the duration of treatment can be increased.

When nitrazepam is used, especially in large doses, daytime drowsiness, a feeling of lethargy, ataxia, impaired coordination of movements, headache, dizziness, dizziness, in rare cases nausea, tachycardia, hyperhidrosis, skin-allergic reactions occur.