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Medication Description: Nitrazepam (Nitrazepamum)

Nitrazepamum (Nitrazepamum). 7-Nitro-2, 3-dihydro-5-phenyl-1H-1, 4-benzodiazepin-2-one:

Synonyms: Mogadon, Neozepam, Radeorm, Enoctin, Apodorm, Benzalin, Calsmin, Dormicum, Dumolid, Epibenzalin, Epinelbon, Eunoctin, Hipnax, Hipsal, Insomin, Livetan, Magadon, Mitidin, Mogadan, Mogadon, apt Pacidrim, Pacisyn, Radedorm, Serenex, Somitran, Sonipam, Sonnolin and others.

Light yellow or light yellow with a greenish tinge crystalline powder. Practically insoluble in water, slightly soluble in alcohol and ether.

The chemical structure and pharmacological properties of nitrazepam are close to the benzodiazepine group tranquilizers (see). The distinctive structural feature of nitrazepam is the presence of the nitro group (NO) at position 7 of the benzodiazepine nucleus.

Like other benzodiaphesin derivatives, nitrazepam has a tranquilizing, anxiolytic (anti-anxiety), muscle relaxant (muscular-relaxing), anticonvulsant action, inhibits conditioned reflexes, and suppresses polysynaptic spinal reflexes. A distinctive feature of nitrazepam is its pronounced hypnotic effect.

Under the influence of nitrazepam increase the depth and duration of sleep. Sleep usually occurs after 45 minutes. after taking the drug and lasts 6-8 hours

Nitrazepam is used for sleep disorders of a different nature, as well as for neuroses of various origins and psychopathies with anxiety prevailing. In combination with other psychotropic drugs, the drug is prescribed to patients with schizophrenia, manic-depressive psychosis (in manic and hypomanic phases), with some organic lesions of the central nervous system (traumatic brain blood circulation disorder), as well as to relieve withdrawal symptoms in chronic alcoholism.

As a sedative and anticonvulsant, nitrazepam in combination with anticonvulsants is prescribed to patients with epilepsy. The drug is also used in anesthesiology practice for sedation and in the postoperative period.

Take nitrazepam inside; as a hypnotic - for half an hour so sleep. The single dose for adults is 0.005-0.01 g (5-10 mg); for children under the age of 1 year, 0.00125– 0.0025 g (1, 25–2, 5 mg), 1–5 years, 0025– 0.005 g (2, 5–5 mg); 6-14 years - 0.005 g (5 mg). Elderly persons are prescribed 0.0025-0.005 g (2, 5-5 mg). The maximum single dose as a soporific for adults is 0.02 g (20 mg). As a tranquilizer and an anticonvulsant, nitrazepam is used 2 to 3 times a day, with 0.005-0.01 g (5-10 mg); if necessary, a single dose of the drug as an anticonvulsant can be increased. The highest daily dose of 0.03 g (30 mg). In course treatment, the duration of nitrazepam is 30 - 45 days. In some cases, the duration of treatment may be increased.

When using nitrazepam, especially in large doses, daytime drowsiness, a feeling of lethargy, ataxia, incoordination of movements, headache, stunnedness, dizziness, in rare cases nausea, tachycardia, hyperhidrosis, skin-allergic reactions are possible.