Description medications: Amantadini hydrochloridum

Midantana (Midantanum). 1-aminoadamantane hydrochloride, or 1-adamantanamine hydrochloride.

Synonyms: Viregit, Adamantin, Amandin, Amantadini hydrochloridum, Amantadine hydrochoride, Amantan, Antadine, Atarin, Fluviatol, Gabirol, Mantadix, Mydantan, Paramentin, Protexin, Symmetrel, Viregit, Virofral, Virosol and others.

The white crystalline powder bitter taste. Soluble in water, readily - alcohol.

The drug was originally proposed as an antiviral agent effective against Type A influenza virus 2. Subsequently, efficacy was observed in parkinsonism.

The mechanism of therapeutic action midantana in Parkinson explained by the fact that it stimulates the release of dopamine from neuronal depot and increases sensitivity of dopaminergic receptors for neurotransmitters (dopamine); Thus, even with a decrease in formation of dopamine in the basal ganglia, the conditions for normalizing them occurring in neurophysiological processes. There is also evidence that midantan inhibits the generation of pulses in the motor neurons of the central nervous system.

Apply midantan in Parkinson's disease and parksinsonizme different etiology. The drug is effective mainly when akinetic and rigid forms, affects less hyperkinetic syndrome (tremor).

Information about midantana effectiveness as a proofreader neuroleptic syndrome are controversial. According to some authors, the medication can be used for this purpose, according to others, its use is inappropriate, since it is ineffective doses medium, and large may cause aggravation of symptoms.

Midantan is a quick preparation, the effect usually occurs in the first days of treatment.

The drug can be administered alone or in combination with other antiparkinsonian agents: holinolitikami and L-dopa.

Midantan Assign inside after eating. Receive, from 0.05 - 0.1 grams, first 2 times, then 3 - 4 times daily. Daily doses of 0.2 - 0.4 g Duration of treatment 2 - 4 months.

The drug is generally well tolerated. In some cases, there may be headache, insomnia, dizziness, weakness, dyspepsia. If necessary, reduce the dose.

Milantan contraindicated in acute and chronic liver and kidney diseases, as well as 6eremennosti. In connection with the possible excitation of CNS drug should be administered with caution to patients with mental disorders, thyrotoxicosis, epilepsy.

Product: pills to 0.1 g-coated yellow, in a package of 100 pieces.

Storage: List B. In dry place.

Rp .: Tab. Midantani 0,1 obd. N. 100

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