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Description medications: Felodipine (Felodipine)

Felodipine (Felodipine).

(±) ethyl, 4- (2,3-dichlorophenyl) -1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid.

Synonym: Plendil, Plendil.

Slightly yellow crystalline powder. Insoluble in water, soluble in ethanol and dichloromethane.

It differs from nifedipine, nicardipine and nitrendipine content with the phenyl ring instead of the nitro group of two chlorine atoms.

It relates to calcium channel blockers prolonged action (up to 24 hours). No effect on the cardiac conduction system.

Completely absorbed in the digestive tract, although the bioavailability of less than 20% (due to the effect of "first pass" through the liver), C max is 2,5-5 h, T ½ - 11-16 hours; excreted mainly by the kidneys.

Applied with arterial hypertension and angina, as well as in Raynaud's disease.

Assign to 0.005 g (5 mg) once a day (morning). If necessary, increase the dose to 0.01 g

Side effects and contraindications are basically the same as that of nifedipine (including his retard forms).

Product: tablets retard 0.0025; 0.005 and 0.01 g (2.5, 5 and 10 mg) (N. 30, 100).