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Description medications: simvastatin (Simvastatin)

Simvastatin (Simvastatin).

1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8- [2- (tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl) ethyl] -1-naphthalenyl -2,2-dimethyl butanoate.

Synonyms: Vasilip, Zocor, Simvor, Simgal, Simgal, Simvor, Synvinolin, Vazilip , Zocor.

White or off-white crystalline powder. Practically insoluble in water, soluble in chloroform, methanol and ethanol.

On chemical structure and mechanism of action similar to lovastatinu.

Like the latter, it is a prodrug (activity seen after metabolism in the body to form a β-hydroxy acid).

Apply with hypercholesterolemia (if there is no therapeutic effect of diet), the combination of hypercholesterolemia and hypertriglyceridemia, coronary heart disease, atherosclerosis, for the prevention of myocardial infarction and stroke.

As published in foreign medical literature data, long (for 5.5 years) receiving simvastatin patients with angina or myocardial infarction resulted in a significant favorable changes in lipid profile of blood plasma (mainly due to lower LDL cholesterol), as well as to improve patient survival rates.

Assign the inside, starting with a dose of 0.01 g (10 mg), 1 per day in the evening during dinner. After approximately 1 month, increase the dose to 0.04 g (1 per day - in the evening or in 2 divided doses of 0.02 g at breakfast and dinner). Most appoint 0.02 1 time per day in the evening. At a dose of 0.08 g has a marked effect gipotriglitseridemicheskoe per day. A distinct clinical effect usually develops within 2 weeks, and the maximum - after 4-6 weeks.

Possible side effects: dyspepsia, exacerbation of hepatitis and pancreatitis, myalgia, myopathy, anemia, depression, paresthesia, peripheral neuropathy, allergic reactions, etc.

Indications are the same as that of lovastatin.

Nicotinic acid (in high doses), immunosuppressants, azole antifungals group (ketoconazole, itraconazole) increase the risk of myopathy and rhabdomyolysis.

It enhances the effects of indirect anticoagulants and gepatoksicheskoe effect of alcohol.

Method of issuance: pills to 0,005; 0.01; 0.02; 0.04, and 0.08 g (N. 14, 28).