Description of the medicine: Simvastatin (Simvastatin)
1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8- [2- (tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl) ethyl] -1-naphthalenyl -2,2-dimethyl butanoate.
Synonyms: Vasilip, Zokor, Simvor, Simgal, Simgal, Simvor, Synvinolin, Vazilip, Zocor.
White or off-white crystalline powder. Practically insoluble in water, soluble in chloroform, ethanol and methanol.
The chemical structure and mechanism of action is close to lovastatin.
Like the latter, it is a prodrug (activity manifests itself after metabolism in the body with the formation of β-hydroxy acids).
Applied with hypercholesterolemia (in the absence of a therapeutic effect from diet therapy), with a combination of hypercholesterolemia and hypertriglyceridemia, ischemic heart disease, atherosclerosis, for the prevention of myocardial infarction and stroke.
According to data published in foreign medical literature, the long-term (for 5.5 years) intake of simvastatin in patients with exertional angina or myocardial infarction led to a significant favorable change in the lipid profile of blood plasma (mainly due to a decrease in LDL cholesterol), as well as improving patient survival rates.
Assign inside, starting with a dose of 0.01 g (10 mg) 1 time per day in the evening during dinner. After about 1 month, increase the dose to 0.04 g (1 time per day - in the evening or in 2 doses of 0.02 g for breakfast and dinner). More often prescribed at 0.02 1 time per day in the evening. At a dose of 0.08 g per day, it has a pronounced hypotriglyceridemic effect. A distinct clinical effect usually develops after 2 weeks and the maximum - after 4-6 weeks.
Possible side effects: dyspepsia, exacerbation of hepatitis and pancreatitis, myalgia, myopathy, anemia, depression, paresthesia, peripheral neuropathy, allergic reactions, etc.
Contraindications are the same as with lovastatin.
Nicotinic acid (in large doses), immunosuppressants, antifungal drugs of the azole group (ketonazole, itraconazole) increase the risk of myopathy and rhabdomyolysis.
Enhances the effects of indirect anticoagulants and the hepatoxic effect of alcohol.
Method of release: tablets at 0.005; 0.01; 0.02; 0.04 and 0.08 g (N. 14, 28).