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Medication Description: Simvastatin (Simvastatin)

Simvastatin (Simvastatin).

1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8- [2- (tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl) ethyl] -1-naphthalenyl -2,2-dimethylbutanoate.

Synonyms: Vasilip, Zokor, Simvor, Simgal, Simgal, Simvor, Synvinolin, Vazilip, Zocor.

White or off-white crystalline powder. Practically insoluble in water, soluble in chloroform, ethanol and methanol.

The chemical structure and mechanism of action is close to lovastatin.

Like the latter, is a prodrug (the activity manifests itself after metabolism in the body with the formation of β-hydroxy acid).

Applied with hypercholesterolemia (with no therapeutic effect from diet therapy), with a combination of hypercholesterolemia and hypertriglyceridemia, coronary artery disease, atherosclerosis, for the prevention of myocardial infarction and stroke.

According to data published in foreign medical literature, prolonged (for 5.5 years) taking simvastatin in patients with exertional angina or who suffered a myocardial infarction led to significant positive changes in the plasma lipid profile (mainly due to a decrease in LDL cholesterol), as well as improve patient survival rates.

Assign inside, starting with a dose of 0.01 g (10 mg) 1 time per day in the evening during dinner. After about 1 month, increase the dose to 0.04 g (1 time per day - in the evening or in 2 doses of 0.02 g at breakfast and dinner). More often prescribed 0.02 1 once a day in the evening. At a dose of 0.08 g per day, it has a pronounced hypotriglyceridemic effect. A distinct clinical effect usually develops after 2 weeks and the maximum - after 4-6 weeks.

Possible side effects: dyspepsia, exacerbation of hepatitis and pancreatitis, myalgia, myopathy, anemia, depression, paresthesia, peripheral neuropathy, allergic reactions, etc.

Contraindications are the same as that of lovastatin.

Nicotinic acid (in large doses), immunosuppressants, antifungals of the azole group (ketonazole, itraconazole) increase the risk of myopathy and rhabdomyolysis.

Enhances the effects of indirect anticoagulants and the hepatoxic effect of alcohol.

Method of production: tablets of 0.005; 0.01; 0.02; 0.04 and 0.08 g (N. 14, 28).