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Description of the medicine: Fluvastatin (Fluvastatin)
FLUVASTATINE (Fluvastatin).
The sodium salt of (±) - (3R, 5S, 6E) -7- [3- (p-fluorophenyl) -1-isopropylindol-2-yl] -3,5, -dioxo-6-heptanoate.
Synonym: Lescola, Lescol.
The first of lipid-lowering statins (inhibitors of HMG-CoA reductase), obtained synthetically.
White or light yellow crystalline powder. Soluble in water, ethanol and methanol. Hygroscopic.
When ingestion absorbed quickly and completely, bioavailability is about 20% (the effect of "first passage" through the liver), T - 2-3 hours; Is excreted mainly with feces.
Applied with primary hypercholesterolemia (mainly types IIa and IIb) with ineffectiveness of diet therapy.
Assign inside, ranging from 0.005 g (5 mg) per day (before bedtime), every 2 weeks, the dose can be increased to 0.02 g (20 mg) at first once a day, then 2 times a day or up to 0.04 G (40 mg) once a day.
Effectively reduces the level of total cholesterol and LDL.
If necessary, to lower the level of triglycerides, it is advisable to use fluvastatin in combination with preparations of anion-exchange resins (see Cholestyramine). When combined with fibrates, the hypolipidemic effect of fluvastatin is enhanced, but a 12-hour break should be taken between fluvastatin and fibrate to avoid side effects.
Possible side effects: dyspepsia, flatulence, insomnia, increased activity of transaminases in the blood, myopathy.
Contraindicated in acute liver disease.
Gemfibrozil, nicotinic acid, erythromycin, immunosuppressants increase the risk of myopathy.
Form release: tablets of 0.02 and 0.04 g (N. 28).
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