Medication Description: Fluvastatin (Fluvastatin)
Sodium salt of (±) - (3R, 5S, 6E) -7- [3- (para-fluorophenyl) -1-isopropylindol-2-yl] -3,5, -dioxy-6-heptanoate.
Synonym: Lescol, Lescol.
The first of the lipid-lowering statins (HMG-CoA reductase inhibitors), obtained synthetically.
White or light yellow crystalline powder. Soluble in water, ethanol and methanol. Hygroscopic.
When ingestion is absorbed quickly and completely, bioavailability is about 20% (the effect of "first passage" through the liver), T Ѕ - 2-3 hours; mainly excreted in faeces.
Applied with primary hypercholesterolemia (mainly types IIa and IIb) with the ineffectiveness of diet therapy.
Assign inside, starting with 0.005 g (5 mg) per day (at bedtime), every 2 weeks the dose can be increased to 0.02 g (20 mg), first 1 time a day, then 2 times a day, or 0.04 g (40 mg) once a day.
Effectively reduces total cholesterol and LDL.
If necessary, reduce the level of triglycerides, it is advisable to use fluvastatin in combination with preparations of anion exchange resins (see Cholestyramine). When combined with fibrates, the hypolipidemic effect of fluvastatin is enhanced, but there should be a 12-hour break between fluvastatin and fibrates in order to avoid side effects.
Possible side effects: dyspepsia, flatulence, insomnia, increased transaminase activity in the blood, myopathy.
Contraindicated in acute liver diseases.
Gemfibrozil, nicotinic acid, erythromycin, immunosuppressants increase the risk of myopathy.
Product form: tablets of 0.02 and 0.04 g (N. 28).