Description of the medicine: Fluvastatin (Fluvastatin)
Sodium salt of (±) - (3R, 5S, 6E) -7- [3- (para-fluorophenyl) -1-isopropylindol-2-yl] -3,5, -dioxy-6-heptanoate.
Synonym: Lescol, Lescol.
The first of lipid-lowering statins (inhibitors of HMG-CoA reductase), obtained synthetically.
White or light yellow crystalline powder. Soluble in water, ethanol and methanol. Hygroscopic.
When taken orally, it is absorbed quickly and completely, bioavailability is about 20% (the effect of "first passage" through the liver), T Ѕ - 2-3 hours; It is excreted mainly with feces.
It is used for primary hypercholesterolemia (mainly types IIa and IIb) with diet therapy ineffective.
Assign inside, starting from 0.005 g (5 mg) per day (at bedtime), every 2 weeks the dose can be increased to 0.02 g (20 mg) at first 1 time per day, then 2 times a day or up to 0.04 g (40 mg) once a day.
Effectively reduces total cholesterol and LDL.
If it is necessary to reduce the level of triglycerides, it is advisable to use fluvastatin in combination with preparations of anion exchange resins (see. Cholestyramine). When combined with fibrates, the hypolipidemic effect of fluvastatin is enhanced, however, between the doses of fluvastatin and fibrates, a 12-hour break should be observed to avoid side effects.
Possible side effects: dyspepsia, flatulence, insomnia, increased activity of transaminases in the blood, myopathy.
Contraindicated in acute liver disease.
Gemfibrozil, nicotinic acid, erythromycin, immunosuppressants increase the risk of myopathy.
Release form: tablets on 0,02 and 0,04 g (N. 28).