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Description medications: Piperacillin (Piperacillin)

Piperacillin (Piperacillin).

Synonyms: ICIPE, Pipraks, Pipratsil, Pitsillin, Picillin, Pipracil, Piprax, Ysipen .

Available in the form of sodium salt.

White or almost white solid. Easily soluble in water.

Semisynthetic antibiotic of the penicillin group. It contains in the molecule a substituted piperazine group (hence the name - piperacillin).

It has a wide spectrum of action. It is active against gram-positive and gram-negative bacteria, obligate anaerobes, Clostridium. Decompose β-lactamases Staphylococcus and some gram negative bacteria but effective against gonococcus producing β-lactamase.

Piperacillin, like azlocillin and carbenicillin, belongs to the so-called pseudomonas penicillins.

After intramuscular injection with max of 30 minutes and the T ½ - 35-70 minutes; It penetrates into all organs and body fluids; derived mainly kidneys unchanged. inside it is not absorbed when taken.

Apply with severe infections (mainly pseudomonas) of the abdominal cavity, the lower respiratory tract, bile and urinary tract infections, upper respiratory tract, skin, soft tissues, bones and joints, in sepsis, endocarditis and other infectious processes.

Enter intravenous slowly (3-5 min) or drip at 0.1-0.15 g / kg per day (in 3-4 receptions), in severe infections - up to 0.2-0.3 mg / kg day, and in life-threatening - 16 g per day. Enter for 3-10 days.

Possible side effects: diarrheal phenomenon, cholestatic hepatitis, somnolence, paraesthesia, leukopenia, neutropenia, thrombocytopenia, bleeding complications, goiter, candidiasis, allergic reactions at the injection site - phlebitis, infiltration.

Product: powder for injection solutions in vials of 1, 2, 3 or 4 years

Piperacillin is a main component of the antibiotic drug combination tazocin resistant to β-lactamases.

Storage: List B.