Before taking the course, consult a doctor!
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Description of the medicine: Rifabutin (Rifabutin)
RIFABUTHIN (Rifabutin).
1 1 , 4-Didehydro-1-deoxy-1,4-dihydro-5 '- (2-methylpropyl) -1-oxorifamycin XIV.
Synonyms: Mycobutin, R-Butin, Mycobutin.
Red and purple powder. Virtually nerastvorim in water, poorly soluble in ethanol, soluble in chloroform and methanol.
Semisynthetic antibiotic. It operates on different types of mycobacteria, including mycobacterium tuberculosis.
Quickly and completely absorbed in the digestive tract, C max is 2-4 h, T S - 35-40 h; Well attached to organs and tissue (the highest concentration is created in the lungs); Is biotransformation in the liver, excreted in the urine and bile.
Used as a backup antituberculous drug. It is also used to prevent the generalization of M. avium-intracellulare infection in HIV-infected patients.
Assign inside (during eating) adults with tuberculosis at 0.15-0.3 g per day in 1 dose (with poor tolerance for 0.15 g 2 times a day), with non-tuberculosis infections - at 0.45-0, 6 g per day.
Possible side effects: nausea, vomiting, bronchospasm, impaired liver function, jaundice, thrombocytopenia, leukopenia, anemia, rash, fever.
The drug is contraindicated in pregnancy, breast-feeding, at the age of 14 years.
Form release: capsules of 0.15 g (N. 15).
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