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Description of the medicine: Stavudine (Stavudine)

STAVUDIN (Stavudine).

1- (2,3-Dideoxy-β-D-glyceropent-2-enofuranosyl) thymine.

Synonym: Zerit, Zerit.

White or off-white crystalline powder. Soluble in water.

In the cells of the body phosphorylates to stavudine triphosphate, which suppresses the activity of reverse transcriptase, which leads to a violation of the synthesis of viral RNA.

When ingested quickly and completely absorbed, bioavailability is about 85%, C max - 1 h, T S - 1.7-3.5 h (with a violation of the kidneys - up to 8 h); Is excreted by the kidneys.

Applied with HIV infection.

Assign inside (1 hour before meals) to adults with a body weight of up to 60 kg of 0.03 g, 60 kg or more - 0.04 grams, children up to 30 kg - 1 mg / kg, 30 kg or more - 0.03 G every 12 hours.

Possible side effects: peripheral neuropathies, dyspepsia, anorexia, impaired pancreatic and liver functions, musculo-articular pain, lymphadenopathy, neutropenia, thrombocytopenia, allergic reactions, etc.

Contraindicated in hepatic failure, breast-feeding.

Forms of release: capsules on 0,015; 0.02; 0.03 and 0.04 g (N. 14, 60); Powder for 0.1% solution (suspension) for oral administration.

Storage: List B.