Medication Description: Menotropins (Menotropins)
Synonyms: Menopausal gonadotropin, Menogon, Pergogrin, Pergonal, Humegon, ChMG Massone, Gonadotrophinum menopausalum, HMH Massone, Humegon, Menogon, Pergogrin, Pergonal.
Gonadotropin menopausal man, containing follicle-stimulating and lutenizing hormones in the ratio of 1: 1; obtained from the urine of women in menopause.
The therapeutic effect is mainly due to the effect of follicle-stimulating hormone (whose C max after intramuscular administration is 6-24 h, T 1/2 -4-12 h).
Apply: in women - with infertility caused by hypothalamic-pituitary disorders (gapogonadotropic hypogonadism), during reproductive procedures; in men, to stimulate spermatogenesis.
They are prescribed intramuscularly for infertility: for women, first, 75-150 IU of follicle-stimulating and luteinizing hormones are administered per day, 1–5 days after the last injection, 5,000–10,000 IU of chorionic gonadropin are administered; men - the same dose of the drug in combination with 1000-3000 ME of chorionic gonadotropin for 3 months.
Possible side effects: ovarian hyperstimulation syndrome (with probable development of ovarian cysts, ascites, hydrothorax, oliguria, hypotension), multiple pregnancy, dyspepsia, fever, arthralgia, myalgia, gynecomastia (in men), allergic reactions.
Contraindications: tumors of the gbtotalamo-pituitary area and genital sphere, hyperprolactinemia, diseases of the kidneys and pancreas; for women, pregnancy, hypertrophy and ovarian cyst, uterine bleeding of unknown etiology, etc.
Product form: lyophilized powder for injection solutions in vials of 75 U (menopausal gonadotropin) and in ampoules of 75 and 150 IU of follicle-stimulating hormone and 35, 70, 75 and 150 IU of luteinizing hormone.