Description of the medicine: Menotropins (Menotropins)
Synonyms: Menopausal gonadotropin, Menogon, Pergogrin, Pergonal, Humegon, ChMG Massone, Gonadotrophinum menopausalum, HMH Massone, Humegon, Menogon, Pergogrin, Pergonal.
Human gonadotropin menopausal containing follicle-stimulating and lutenizing hormones in a ratio of 1: 1; obtained from the urine of menopausal women.
The therapeutic effect is mainly due to the influence of follicle-stimulating hormone (C max of which after intramuscular injection is 6-24 hours, T 1/2 -4-12 hours).
Apply: in women - with infertility due to hypothalamic-pituitary disorders (hapogonadotropic hypogonadism), during reproductive procedures; in men - to stimulate spermatogenesis.
Assign intramuscularly for infertility: women - first 75-150 IU follicle-stimulating and luteinizing hormones per day, 1-2 days after the last injection, 5000-10 000 IU chorionic gonadotropin is administered; men - the same doses of the drug in combination with 1000-3000 ME chorionic gonadotropin for 3 months.
Possible side effects: ovarian hyperstimulation syndrome (with the possible development of ovarian cysts, ascites, hydrothorax, oliguria, arterial hypotension), multiple pregnancy, dyspepsia, fever, arthralgia, myalgia, gynecomastia (in men), allergic reactions.
Contraindications: tumors of the gtotalamo-pituitary region and genital area, hyperprolactinemia, kidney and pancreas diseases; for women - pregnancy, hypertrophy and ovarian cyst, uterine bleeding of unknown etiology, etc.
Release form: lyophilized powder for injection in bottles of 75 IU (menopausal gonadotropin) and in ampoules of 75 and 150 IU of follicle-stimulating hormone and 35, 70, 75 and 150 IU of luteinizing hormone.