Description of the medicine: Fenkarol (Phencarolum)

FENCAROL (Phencarolum).

Chinuclidyl-3-diphenylcarbinol hydrochloride.

Synonyms: Quifenadine, Quifenadinum.

White crystalline powder odorless, bitter taste. Malorastvorim in the will and alcohol.

Fenkarol is the original domestic protivogistaminnym drug, blocking H 1 -receptors. Possessing high antihistaminic activity, it is very effective in the treatment of allergic diseases'.

Fenkarol has low lipophilicity, poorly penetrates the blood-brain barrier and unlike dimedrol and diprazine does not have any expressed sedative and hypnotic effect. The drug does not possess adrenolytic and cholinolytic activity.

There are indications that fenkarol has antiarrhythmic activity. It is possible that this is due to the presence of a quinuclidine core in its molecule, since the antiarrhythmic effect is also characteristic of other derivatives of quinuclidine (see Oxylidinum).

The mechanism of action of fenkarol differs from dimedrol and other antihistamines: it not only blocks H 1 -receptors, but also reduces the content of histamine in tissues, which is due to its ability to activate diaminoksidazu - an enzyme that inactivates histamine.

Fenkarol is low in toxicity. Absence of pronounced holinoliticheskogo action allows you to assign it to patients who are contraindicated with antihistamines that have anticholinergic activity.

Apply fenkarol with pollinosis, for the treatment of acute and chronic urticaria, angioedema, Quincke, hay fever, allergic rhinitis, dermatoses (eczema, neurodermatitis, skin itching, etc.), allergic complications associated with the use of drugs, food intake, etc. .

Apply fenkarol inside (after eating). The dose for adults is 0.025-0.05 g 3 - 4 times a day. The length of the course of treatment depends on the nature and course of the disease; An average of 10 to 20 days. If necessary, repeat courses. Children are prescribed in the following doses: at the age of 3 years - 0,005 grams 2-3 times a day, from 3 to 7 years - 0.01 g 2 times a day, from 7 to 12 years 0.01 to 0.015 grams 2-3 times a day, over 12 years - 0.025 grams 2-3 times a day.

The drug is well tolerated. In some cases, dry mouth and dyspeptic phenomena that occur independently or with a decrease in dose are possible.

The absence of a pronounced sedative effect makes it possible to use fenccarol to persons whose work requires a quick physical or mental reaction (transport drivers, etc.) and which is contraindicated in the use of diphenhydramine, diprazine and other antihistamines during work. Taking into account, however, the possibility of individually hypersensitive to the drug, it is necessary to establish before the beginning of systematic treatment whether the patient is not observed sedative or hypnotic action after taking the drug.