Description of the medicine: Phencarolum
Synonyms: Quifenadine, Quifenadinum.
Flavourless white crystalline powder, bitter taste. Slightly soluble in will and alcohol.
Fenkarol is an original domestic anti-histamine drug that blocks H 1 receptors. With its high anti-histamine activity, it is very effective in the treatment of allergic diseases. '
Fenkarol has low lipophilicity, poorly penetrates the blood-brain barrier and, unlike diphenhydramine and diprazine, does not have any pronounced sedative and hypnotic effects. The drug does not have adrenolytic and anticholinergic activity.
There are indications that fencarol has antiarrhythmic activity. It is possible that this is due to the presence of a quinuclidine nucleus in its molecule, since the antiarrhythmic effect is also characteristic of other quinuclidine derivatives (see Oxilidine).
According to the mechanism of action, fencarol differs from diphenhydramine and other antihistamines: it not only blocks H 1 receptors, but also reduces the histamine content in tissues, which is associated with its ability to activate diamine oxidase, an enzyme that inactivates histamine.
Fenkarol is low toxic. The absence of a pronounced anticholinergic effect allows it to be prescribed to patients who are contraindicated in antihistamines with anticholinergic activity.
Fencarol is used for pollinosis, for the treatment of acute and chronic urticaria, Quincke's angioedema, hay fever, allergic rhinitis, dermatoses (eczema, neurodermatitis, skin itching, etc.), allergic complications associated with the use of drugs, food intake, etc. .
Apply fenkarol inside (after eating). The adult dose is 0.025-0.05 g 3 to 4 times a day. The duration of treatment depends on the nature and course of the disease; an average of 10 to 20 days. If necessary, conduct repeated courses. Children are prescribed in the following doses: under the age of 3 years - 0.005 g 2 to 3 times a day, from 3 to 7 years - 0.01 g 2 times a day, from 7 to 12 years old from 0.01 to 0.015 g 2-3 times a day, over 12 years old - 0.025 g 2-3 times a day.
The drug is well tolerated. In some cases, dry mouth and dyspeptic symptoms, occurring on their own or with a decrease in dose, are possible.
The absence of a pronounced sedative effect allows the use of fencarol to individuals whose work requires a quick physical or mental reaction (drivers of vehicles, etc.) and who are advised not to use diphenhydramine, diprazine and other antihistamines during their work. Considering, however, the possibility of individually hypersensitivity to the drug, it should be established before the start of systematic treatment whether the patient has a sedative or hypnotic effect after taking the drug.