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Description drugs: digitalis ()

Digitalis (purple and grandiflora).

Purple Foxglove (Digitalis purpurea L.), herewith. figwort (Scrorhulariaseae) - biennial herbaceous plant native to Western Europe; introduced into the culture in our country. Pharmacopoeia allows for use on a par with it, Digitalis grandiflora (Digitalis grandiflora Mill, syn Digitalis ambigua Murr...) Of the same family; It grows in the European part of our country, in the North Caucasus, the Urals.

Apply the dried leaves of the foxglove (Folia Digitalis) MANUFACTURING lennye of these drugs. Leaves contain glycosides, saponins and other substances.

In 1 g of leaves of digitalis should contain 50 - 66 10.3 12 or ICE, 6 CUD. During storage, especially under adverse conditions, the leaves of the asset is reduced.

Digitalis purpurea leaves contain a number of primary (or genuinnyh) glycosides (purpureaglikozidy A and B, etc..), Losing by drying and storage under the influence of enzymes and sugar molecules are transformed into WTO hexadecimal glycosides, which are the active ingredients of drugs digitalis. The most important of the secondary glycosides - digitoxin and ghee toxin - composed of aglycone (digitoksigenin and gitoksigenin) and three sugar residues wasps - digitoxose.

Digitalis glycosides are purple, especially digitoxin, characterized greatest resistance in the organism compared to other cardiac glycosides. They are a little broken at intake and at the same time have a method of administering a pronounced therapeutic effect. Their action develops usually complete after 8 - 12 hours after administration. They are slowly removed from the body and are characterized (especially digitoxin) a high degree of accumulation.

digitalis drugs prescribed for all degrees of chronic serdech insufficiency (decompensation) of different origin: the E sweeping vices koronarokardioskleroze, hypertension, distro raphy myocardium, as well as atrial fibrillation, paroxysmal before the atrial, nodal (atrioventricular) tachycardia and other arrhythmias .

During the treatment should be carefully monitored for the cardiovascular system and the general state of the patients. When properly used digitalis drugs should be observed side effects. It is necessary to consider the possibility of individual sensitivity of the patient.

Duration of use of digitalis drugs is determined by the terms of circulation and restore a normal heart rate, urine output normalization, disappearance of edema and a corresponding decrease in patient weight, improve sleep and general condition. Typically, digitalis preparations take a long time.

Depending on the severity of side effects is necessary to reduce the dose or temporarily stop taking the drugs. To reduce evolved methoxy cal phenomena prescribe atropine, caffeine, potassium chloride, unitiol, and if necessary - antiarrhythmic drugs (see.).