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Description of the medicine: Fluphenazine decanoate (Fluphenazine decanoate)
FLUFENAZINE DECANATE (Fluphenazine decanoate). 2-Trifluoromethyl-10- {3- [1- (b-capranoyloxyethyl) -piperazinyl-4] -propyl} -phenothiazine.
Synonyms: Lyorodin Depot, Moditen Depot, Fluorophenazine Decanoate, Fluoromazine Depot, Moditene Depo, Modecate, Mirenil-retard, Flunazol, Lyogen-depo, Lyoridin-depo, Lyogen-retard, Modecat, Moditen-depo, Fluphenazinum decanoate, Phthorphenazinum decanoate.
Strong antipsychotic, prolonged action. The prolonged effect is associated with a change in the chemical structure of fluorophenazine (esterification with a capric acid residue), which increases the relative molecular weight of the preparation and gives it a high lipophilicity. In a suitable dosage form (solution in oil), the drug after a single intramuscular injection acts depending on the dose up to 1 - 2 weeks or more. Long-term preservation of the drug in the body determines its high efficiency and features of the therapeutic effect. The drug is most effective for neurotic-like and hallucinatory disorders.
Assign as an antipsychotic with a pronounced antipsychotic effect, which has an activating and weak sedative effect, with different forms of schizophrenia, especially in the presence of stuporato-catatonic disorders, with paranoid conditions that occur with affect of fear, with a sluggish course of the process with a predominance of depressive-apathic states, etc. .
The drug is indicated for patients with a long-term adverse course of schizophrenia. In some cases, it has a therapeutic effect with insufficient activity of other (non-protracted) neuroleptic drugs.
In connection with long-term action is convenient for use in patients who are difficult to appoint antipsychotics in the usual form. To a greater extent than conventional (non-protracted) drugs, it is convenient for outpatient treatment and facilitates the patients' readaptation.
The drug is widely used for anti-relapse maintenance therapy for schizophrenia. However, it is necessary to take into account the following: despite the fact that with the use of the drug attacks occur less often, treatment does not completely prevent relapses and after a long time (about 5 years), a number of patients experience a weakening of the anti-relapse effect, Antipsychotic drugs.
Apply fluorophenazine-decanoate intramuscularly. Enter 12, 5 - 25 mg, sometimes 50 mg (0.5 - 2 ml of 2, 5% solution) once every 1 to 3 weeks. In the therapeutically-resistant cases of paranoid schizophrenia, 1 to 4 ml of a 2.5% solution (25-100 mg) were administered once every 1 to 3 weeks.
When applying the drug, there may be phenomena of parkinsonism, akathisia, finger tremor, etc. To prevent and arrest these phenomena, cyclodol or other anticholinergic antiparkinsonian drugs are prescribed.
Form release: 2, 5% solution in oil in ampoules of 1 ml (25 mg in 1 ampoule).
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