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Description of the medicine: Fluphenazine decanoate (Fluphenazine decanoate)

FLUFENAZINE DECANOATE (Fluphenazine decanoate). 2-Trifluoromethyl-10- {3- [1- (b-capranoyloxyethyl) -piperazinyl-4] propyl} phenothiazine.

Synonyms: Liorodin Depot, Moditen Depot, Fluorophenazine Decanoate, Fluormenazine Depot, Moditen Depot, Modecate, Mirenil-Retard, Flunazol, Lyogen-depo, Lyoridin-depo, Lyogen-retard, Modecat, Moditen-depo, Fluphenazin decano Phthorphenazinum decanoate.

Strong antipsychotic with a prolonged effect. The prolonged effect is associated with a change in the chemical structure of fluorophenazine (esterification with a capric acid residue), which increases the relative molecular weight of the drug and gives it high lipophilicity. In the appropriate dosage form (solution in oil), the drug after a single intramuscular injection acts, depending on the dose, for 1 to 2 weeks or more. Long-term preservation of the drug in the body determines its high effectiveness and features of the therapeutic effect. The drug is most effective for neurosis-like and hallucinatory disorders.

Assign as an antipsychotic with a pronounced antipsychotic effect, with an activating and weak sedative effect, with various forms of schizophrenia, especially in the presence of stupor-catatonic disorders, with paranoid states that occur with the affect of fear, with a sluggish course of the process with a predominance of depressive-apatic states, etc. .

The drug is indicated for patients with a prolonged adverse course of schizophrenia. In some cases, it has a therapeutic effect with insufficient activity of other (non-prolonged) antipsychotics.

In connection with a long-term action, it is convenient for use in patients who have difficulty prescribing antipsychotics in their usual form. To a greater extent than conventional (non-prolonged) drugs, it is convenient for outpatient treatment and facilitates the readaptation of patients.

The drug is widely used for anti-relapse maintenance therapy for schizophrenia. However, it is necessary to take into account the following: despite the fact that when using the drug, seizures occur less frequently, nevertheless, treatment does not completely prevent relapses and after a long period of time (approximately 5 years) some patients experience a weakening of the anti-relapse effect, which necessitates the use of other antipsychotic drugs.

Apply fluorophenazine decanoate intramuscularly. 12, 5 - 25 mg, sometimes 50 mg (0.5 - 2 ml of 2, 5% solution) are administered once every 1 to 3 weeks. In therapeutically resistant cases of paranoid schizophrenia, 1–4 ml of a 2.5% solution (25–100 mg) was administered every 1–3 weeks.

When using the drug, the phenomena of parkinsonism, akathisia, tremor of fingers, etc. are possible. To prevent and stop these phenomena, cyclodol or other anticholinergic anticholinergic drugs are prescribed.

Release form: 2, 5% solution in oil in ampoules of 1 ml (25 mg in 1 ampoule).