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Description of the drug: Prolonged dosage forms of nitrosorbide ()

PROLONGED MEDICINAL FORMS OF NITROSORBID.

Dinitrosorbilong (Dinitrosorbilong).

Polymeric drug films (plates) containing nitrosorbide by 0,02 or 0,04 g.

Plates blue in oval or rectangular shape. For a dose of 0.02 g (20 mg), their size is 9 × 4, 5 × 1, 2 mm; For a dose of 0.04 g (40 mg) 12 x 7 x 1, 2 mm.

At +37 'C the films dissolve in water for 2-6 h.

Applied as a prolonged form of nitrosorbide to prevent attacks of angina and in heart failure.

Assign the application (gluing) of the plate on the gum of the upper jaw in front at the level of the incisors or small molars, each time alternating sides. The onset of action is an average of 5 minutes after the application. Take 1 - 3 times a day. The duration of the effect after a single application of the plate is up to 8 hours.

The drug should be administered to patients before the long-term physical or emotional stress, as well as suffering angina attacks at night or in the early morning hours.

The form of release: films (plates) on 10 pieces in contour film packing (on 50 pieces in a cardboard pack) and in a glass test tube on 50 pieces.

Storage: List B. In the dark place away from the fire.

Various prolonged preparations of nitrosorbide. A number of prolonged preparations of nitrosorbide have been developed abroad, including Isoket retard, Kardiket K Isomak retard rd, Isosorbet reder, etc. (Isoket retard, Sardiket, Isomack rétrade, Isosorb rétard) - tablets or capsules containing 20; 40 or 60 mg of nitrosorbide; Isostenase-40 (Isostease reter) - capsules containing 40 mg of nitrosorbide.

The action of all these drugs comes later, but lasts longer than the usual tablets of nitrosorbide. Take them 1 tablet (capsule) 2 (rarely 3) times a day.

It should be borne in mind that when taking all prolonged drugs nitrosorbide there is a greater likelihood of developing tolerance than when taking conventional tablets.