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Medication Description: Euphyllinum (Euphyllinum)

Euphyllinum (Euphyllinum).

Theophylline with 1, 2-ethylenediamine. The content of theophylline is about 80%, ethylenediamine - 20%.

Synonyms: Aminophyllin, Aminocardol, Aminophyllinum, Ammophyllin, Diaphyllin, Genophyllin, Methaphyllin, Neophyllin, Novphyllin, Synthophyllin, Theophyllamin, Theophylline ethylendiamine, etc.

White or white with a yellowish sheen crystalline powder with a faint smell of ammonia. Soluble in water. Aqueous solutions (pH 9, 0 9, 7) are prepared aseptically.

The effect of aminophylline is due primarily to its theophylline content. Ethylenediamine increases the antispasmodic activity and promotes the dissolution of the drug. The molecular mechanism of action of aminophylline is basically similar to that of theophylline.

Important features of aminophylline are its solubility in water and the possibility of its parenteral (intravenous) administration.

Like theophylline, aminophylline relaxes the muscles of the bronchi, lowers the resistance of blood vessels, dilates the coronary vessels, lowers the pressure in the pulmonary artery system, increases renal blood flow, has a diuretic effect associated mainly with a decrease in tubular reabsorption; causes an increase in urine excretion of water and electrolytes, especially sodium ions and chlorine.

The drug greatly inhibits platelet aggregation.

Euphyllinum is used in case of bronchial asthma and bronchial spasms of various etiologies (mainly for the onset of attacks); hypertension in the pulmonary circulation, as well as in cardiac asthma, especially when the seizures are accompanied by bronchiolitis and breathing disorders like Cheyn Stokes. It is also recommended for stopping cerebral vascular crises of atherosclerotic origin and improving cerebral circulation, reducing intracranial pressure and brain edema in ischemic strokes, as well as in chronic cerebrovascular insufficiency. The drug improves renal blood flow and can be used with appropriate indications.

Assign aminophylline inside, in the muscles, veins and microclysters. Under the skin, aminophylline solutions are not injected, as they cause tissue irritation.

The route of administration depends on the characteristics of the case: for acute attacks of bronchial asthma and stroke, it is administered intravenously, in less severe cases, intramuscularly or orally.

Inside adults take 0.15 g after meals 1 - 3 times a day. Children inside give the rate of 7 - 10 mg / kg per day in 4 divided doses. The duration of treatment is from several days to several months.

Adults are slowly injected into a vein (within 4-6 minutes) in a dose of 0.12 to 0.24 g (5-10 ml of a 2, 4% solution), which are previously diluted in 10-20 ml of isotonic sodium chloride solution. With the appearance of palpitations, dizziness, nausea, the rate of administration is slowed down or transferred to drip, for which 10 to 20 ml of a 2, 4% solution (0.24 0.48 g) is diluted in 100-150 ml of isotonic sodium chloride solution; enter with a speed of 30 - 50 drops per minute. If it is impossible to inject into the vein, intramuscular injection of 1 ml of 24% solution.