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Description of the medicine: Euphyllinum (Euphyllinum)

EUFILLIN (Euphyllinum).

Theophylline with 1, 2-ethylenediamine. Theophylline content is about 80%, ethylenediamine - 20%.

Synonyms: Aminophylline, Aminocardol, Aminophyllinum, Ammophyllin, Diaphyllin, Genophyllin, Methaphyllin, Neophyllin, Novphyllin, Synthophyllin, Theophyllamin, Theophylline ethylendiamine, etc.

Crystalline powder, white or yellowish in color, with a faint smell of ammonia. Soluble in water. Aqueous solutions (pH 9.0 9.7) are prepared aseptically.

The effect of aminophylline is primarily due to the content of theophylline in it. Ethylenediamine enhances antispasmodic activity and helps dissolve the drug. The molecular mechanism of action of aminophylline is basically similar to the mechanism of action of theophylline.

Important features of aminophylline are its solubility in water and the possibility of its parenteral (intravenous) administration.

Like theophylline, aminophylline relaxes the muscles of the bronchi, lowers the resistance of blood vessels, dilates the coronary vessels, lowers the pressure in the pulmonary artery system, increases renal blood flow, has a diuretic effect, mainly associated with a decrease in tubular reabsorption; causes an increase in urinary excretion of water and electrolytes, especially sodium and chlorine ions.

The drug greatly inhibits platelet aggregation.

Eufillin is used for bronchial asthma and bronchial spasm of various etiologies (mainly for the relief of seizures); hypertension in the pulmonary circulation, as well as with cardiac asthma, especially when seizures are accompanied by bronchiolospasm and respiratory disorders according to the type of Chain Stokes. It is also recommended for stopping cerebral vascular crises of atherosclerotic origin and improving cerebral circulation, reducing intracranial pressure and cerebral edema in ischemic strokes, as well as in case of chronic cerebrovascular insufficiency. The drug improves renal blood flow and can be used if appropriate.

Eufillin is prescribed orally, in the muscles, vein and microclysters. Eufillin solutions are not administered under the skin, as they cause tissue irritation.

The route of administration depends on the particular case: in acute attacks of bronchial asthma and strokes administered intravenously, in less severe cases, intramuscularly or orally.

Inside, adults take 0.15 g after eating 1 to 3 times a day. Children inside are given at the rate of 7 - 10 mg / kg per day in 4 divided doses. The duration of treatment is from several days to several months.

0.12 0.24 g (5-10 ml of 2, 4% solution), which are previously diluted in 10-20 ml of isotonic sodium chloride solution, is injected into a vein for adults slowly (within 4-6 minutes). With the appearance of palpitations, dizziness, nausea, the rate of administration is slowed down or goes on drip, for which 10 - 20 ml of a 2, 4% solution (0.24 0.48 g) is diluted in 100 - 150 ml of an isotonic sodium chloride solution; administered at a rate of 30 to 50 drops per minute. If it is impossible to inject into the vein, intramuscularly injected 1 ml of a 24% solution.