Medication Description: Angiotensinamide (Angiotensinamidum)
Angiotensinamide, manufactured for medical use in the form of a drug for injection (Angiotensinamidum priro injestionibus), is L-asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine acetate.
Synonyms: IL-Asparagil-5-L-valan-hyotensin II, Hypertensin, Nuretensin.
White lyophilized powder with a faint odor of acetic acid. Easily soluble in water, a little - in alcohol.
Angiotensinamide has a strong pressure effect, due to the increased peripheral resistance of blood vessels, especially small caliber arterioles. The tone of the veins affects slightly.
Under the influence of angiotensinamide, the vessels of the internal organs, skin, kidneys are particularly narrowed. Blood circulation in skeletal muscles and coronary vessels does not change significantly. The drug has no direct effect on the heart and does not cause arrhythmias in therapeutic doses.
The drug also has the ability to reduce the smooth muscles of the uterus, intestines, bladder and gall bladders. It stimulates adrenaline secretion from the adrenal glands and aldosterone production.
Angiotensinamide is quickly inactivated by enzymes contained in the blood, and therefore with a single injection has a short-term (2 - 3 min) pressure effect. However, the duration of the effect can be relatively easily controlled by selecting the appropriate rate of administration of the drug solution (intravenous drip).
Applied with shock conditions, especially with isovolemic shock associated with vasomotor collapse (post-traumatic and postoperative shock, shock during intoxication, coma and infectious diseases, as well as myocardial infarction, cardiac tamponade, massive pulmonary embolism, etc.). In cardiogenic shock, in cases involving constrictor reaction of peripheral vessels, the drug should be used with great caution (see Noradrenaline).
Injected intravenously by slow drip infusion.
An isotonic solution of sodium chloride or a 5% glucose solution is used to dissolve lyophilized angiotensinamide.
From the total amount of solvent required for infusion, 10 ml are taken up with a syringe and injected through a rubber stopper into a vial with angiotensinamide. The contents of the vial are thoroughly shaken until the powder is completely dissolved. Then this solution is transferred by syringe into the remaining amount of solvent.
Due to the presence in the blood of the enzyme angiotensinase, the drug should not be diluted with blood and serum. Depending on the speed of administration, a solution of the drug is prepared in a concentration of from 1 to 50 μg in 1 ml (for slow administration - low concentrations).
To prepare a concentration of 1 μg / ml, the contents of 1 vial (1 mg of the preparation) are dissolved in 1000 ml of solvent, and for a concentration of 50 μg / ml in 20 ml of solvent.