Description of the medicine: Angiotensinamide (Angiotensinamidum)
Angiotensinamide, available for medical use in the form of an injectable preparation (Angiotensinamidum ppo injibtionibus), is L-asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-hydidyl-L-prolyl-L-phenylalanine acetate.
Synonyms: IL-Asparagil-5-L-valylan-hyotensin II, Hypertensin, Nurertensin.
White lyophilized powder with a slight smell of acetic acid. Easily soluble in water, little in alcohol.
Angiotensinamide has a strong pressor effect due to increased peripheral resistance of blood vessels, especially small-caliber arterioles. It affects the tone of the veins slightly.
Under the influence of angiotensinamide, the vessels of the internal organs, skin, and kidneys are especially narrowed. Blood circulation in skeletal muscles and coronary vessels does not change significantly. The drug does not have a direct effect on the heart and does not cause arrhythmias in therapeutic doses.
The drug also has the ability to reduce the smooth muscles of the uterus, intestines, urinary and gall bladders. It stimulates the release of adrenaline from the adrenal glands and the production of aldosterone.
Angiotensinamide is rapidly inactivated by enzymes in the blood, and therefore, with a single injection, it has a short-term (2–3 min) pressor effect. However, the duration of the effect can be relatively easily adjusted by selecting the appropriate rate of administration of the drug solution (drip intravenously).
It is used for shock conditions, especially for isovolemic shock associated with vasomotor collapse (post-traumatic and postoperative shock, shock with intoxication, coma and infectious diseases, as well as myocardial infarction, cardiac tamponade, massive pulmonary embolism, etc.). In case of cardiogenic shock, in cases accompanied by a constrictor reaction of peripheral vessels, the drug should be used with great care (see Noradrenaline).
Enter intravenously by slow drip infusion.
To dissolve lyophilized angiotensinamide, an isotonic sodium chloride solution or 5% glucose solution is used.
From the total amount of solvent necessary for infusion, 10 ml are taken with a syringe and injected through a rubber stopper into the vial with angiotensinamide. The contents of the vial are thoroughly shaken until the powder is completely dissolved. Then this solution is transferred with a syringe into the remaining amount of solvent.
Due to the presence of angiotensinase enzyme in the blood, the drug should not be diluted with blood and blood serum. Depending on the rate of administration, a solution of the drug is prepared in a concentration of 1 to 50 μg in 1 ml (for slow administration, low concentrations).
To prepare a concentration of 1 μg / ml, the contents of 1 vial (1 mg of the drug) are dissolved in 1000 ml of solvent, and for a concentration of 50 μg / ml in 20 ml of solvent.