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Description of the medicine: Ergotamine (Ergotamini hydrotartras)

ERGOTAMINE. Available in the form of ergotamine hydrotartrate (Ergotamini hydrotartras).

Synonyms: Cornutamine, Cornutamin, Ergotamine hydrotartrate, Ergotartrat, Femergin, Gynecorn, Gynergen, Gynofort, Secotamin, Synergan, etc.

Flavourless crystalline powder, white or white with a slightly grayish or creamy tint. Slightly soluble in water and alcohol.

Strengthens the rhythmic contractions of the uterus and increases its tone; in comparison with ergometrin, it acts longer, although the effect develops somewhat more slowly.

Used in obstetric and gynecological practice in the early postpartum period with hypo- and atonic bleeding, during and after cesarean section, with subinvolution of the uterus after childbirth and abortion, profuse dysfunctional uterine bleeding and hemorrhages associated with uterine fibroids.

Assign inside 10-15 drops of a 0.1% solution (or 40 drops of a 0.025% solution) or 1 tablet (dragee) of 0.001 g 1-3 times a day.

0.5-1.0 ml (0.25-0.5 mg) of a 0.05% solution is administered under the skin and intramuscularly. In urgent cases, 0.5 ml of a 0.05% solution is slowly injected into a vein.

Due to the effect on cerebral circulation, ergotamine is also used in the treatment of migraine.

Take 15 to 20 drops of a 0.1% solution several hours before the expected attack. You can also put 2 - 4 mg under the tongue at the beginning of the pain phase of the attack, then after 2 hours - 2 mg until the pain decreases, but not more than 10 mg per day. In a severe migraine attack, 0.5-1.0 ml of a 0.05% solution is administered intramuscularly.

Higher doses for oral administration: single-dose 0.002 g (2 mg), daily 0.004 g (4 mg); under the skin and intramuscularly; single 0.0005 g (0.5 mg), daily 0.002 g (2 mg).

Ergotamine is not recommended for a long time (to avoid the occurrence of ergotism); after 7 days of use in cases requiring longer treatment, take a break (for 3 to 4 days).

In some cases, nausea, vomiting, and diarrhea are possible.

Contraindications: angina pectoris and narrowing of peripheral vessels, late stages of atherosclerosis and hypertension, pregnancy, septic conditions, impaired liver and kidney function.

Method of release: 0.05% solution in ampoules of 1 ml (0.5 mg in 1 ml); 0.1% solution in 10 ml vials (1 mg in 1 ml); tablets (pills) at 0.001 g (1 mg).

Storage: List A. In the dark place at a temperature of no higher than + 10 C.

Rp .: Sol. Ergotamini hydrotartratis 0.05% 1 ml

DtdN 3 in ampull.

S. 0.5 to 1 ml per muscle or under the skin

Rp .: Sol. Ergotamini hydrotartratis 0.1% 10 ml

DS Take 10 drops orally 2 to 3 times a day

Rp .: Tab. Ergotamini hydrotartratis 0.001 N. 10

DS Take 1 tablet orally 2 to 3 times a day

Ergotamine is an integral part of the "Cofetamine" tablets (see Caffeine) and "Belloid" (see belladonna preparations).