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Medication Description: Ergotamine (Ergotamini hydrotartras)

ERGOTAMIN. Available in the form of ergotamine hydrotartrate (Ergotamini hydrotartras).

Synonyms: Cornutamine, Cornutamin, Ergotamine hydrotartrate, Ergotartrat, Femergin, Gynecorn, Gynergen, Gynofort, Secotamin, Synergan, etc.

White or white with a slightly grayish or creamy tint, odorless crystalline powder. It is soluble in water and alcohol.

Strengthens rhythmic contractions of the uterus and increases its tone; compared to ergometrine, it has a longer duration, although the effect develops somewhat slower.

Used in obstetric and gynecological practice in the early postpartum period with hypo-and atonic bleeding, during and after cesarean section, with subinvolution of the uterus after childbirth and abortion, abundant dysfunctional uterine bleeding and hemorrhages associated with uterine myomas.

Assign inside 10 to 15 drops of a 0.1% solution (or 40 drops of a 0.025% solution) or 1 tablet (dragee), 0.001 g, 1 to 3 times a day.

Under the skin and intramuscularly injected with 0.5 - 1, 0 ml (0.25 - 0.5 mg) 0.05% solution. In urgent cases, 0.5 ml of a 0.05% solution is slowly injected into a vein.

In connection with the effect on cerebral circulation ergotamine is also used in the treatment of migraine.

Take 15-20 drops of 0.1% solution a few hours before the expected attack. You can also at the beginning of the painful phase of the attack put 2 - 4 mg under the tongue, then after 2 h - 2 mg to reduce pain, but not more than 10 mg per day. In a severe migraine attack, a 0.5-1.0 ml of 0.05% solution is injected intramuscularly.

Higher doses by ingestion: single 0.002 g (2 mg), daily 0.004 g (4 mg); under the skin and intramuscularly; a single 0.0005 g (0.5 mg) daily 0.002 g (2 mg).

Ergotamine is not recommended for a long time (in order to avoid the effects of ergotism); after 7 days of use in cases requiring a longer treatment, they take a break (for 3–4 days).

In some cases, possible nausea, vomiting, diarrhea.

Contraindications: angina pectoris and peripheral vasoconstriction, late stages of atherosclerosis and hypertension, pregnancy, septic conditions, disorders of the liver and kidneys.

Method of issuance: 0.05% solution in ampoules of 1 ml (0.5 mg in 1 ml); 0.1% solution in vials of 10 ml (1 mg in 1 ml); tablets (dragee) on 0,001 g (1 mg).

Storage: List A. In the dark place at a temperature of not more than + 10 C.

Rp .: Sol. Ergotamini hydrotartratis 0.05% 1 ml

DtdN 3 in ampull.

S. At 0.5 - 1 ml in the muscle or under the skin

Rp .: Sol. Ergotamini hydrotartratis 0,1% 10 ml

DS Take 10 drops inside 2 - 3 times a day.

Rp .: Tab. Ergotamini hydrotartratis 0,001 N. 10

DS Take orally 1 tablet 2 - 3 times a day

Ergotamine is an integral part of the Caffetamine tablets (see Caffeine) and <Belloid> (see belladonna preparations).