Description of the medicine: Clomiphen citras

Clomiphen citras. 1- [4- (2-Diethylaminoethoxy) phenyl] -1,2-diphenyl-2-chloroethylene citrate.

Synonyms: Clostilbegite, Ardomon, Chloramiphene, Clomid, Clomifeni citras, Clomivid, Clostilbergyt, Dyneric, Fertilin, Fertomid, Genozym, Gravosan, Nefimol, Omifin, Pergolime, Prolifen, Serofen and others.

White or white with a creamy shade of crystalline powder, slightly soluble in water, sparingly soluble in alcohol.

The preparation is a mixture of the cis and trans forms of said compound; The cis isomer is more active, the content of which in the preparation is not less than 50%.

According to the chemical structure, the chlorotrianizene is related (see) - a drug with estrogenic activity and tamoxifen (an antiestrogenic drug).

Clomiphene citrate refers to a group of drugs called anti-estrogens. Preparations of this group specifically bind to estrogen-dependent receptors (estrogen receptors) in the hypothalamus and ovaries. In small doses, they increase the secretion of gonadotropins (prolactin, follicle-stimulating and luteinizing hormones) and stimulate ovulation. With a low content of endogenous estrogens in the body, these drugs have a moderate estrogenic effect, but with a high level of estrogens they have an antiestrogenic effect. Reducing the level of circulating estrogens (oppressive in large concentrations of secretion of gonadotropic hormones), they contribute to increased secretion of gonadotropins. In large doses, these drugs can inhibit the secretion of gonadotropins. They have no gestagenic and androgenic activity.

In connection with these properties, clomiphen citrate in appropriate doses is used as a means to stimulate ovulation in anovulatory ovarian dysfunction and associated infertility, as well as dysfunctional uterine bleeding, disgonadotropic forms of amenorrhea, and other pathologies associated with endocrine disruption of ovulation.

Clomiphene citrate is also used in breast cancer.

In connection with the stimulation of the secretion of gonadotropins, clomiphen citrate is also used in the case of androgen deficiency, oligospermia in men and in the retardation of sexual and physical development in adolescent males.

They are used to diagnose disorders of the gonadotropic function of the pituitary gland.

Clomiphene citrate can be used in combination with preparations of gonadotropic hormones. It is well absorbed when ingested and slowly excreted from the body; The half-life of the drug in the body is 5 - 7 days.

Take clomiphen citrate inside (regardless of the time of eating).

For stimulation of ovulation appoint inwards at a dose of 50 mg (0.05 g) 1 times a day (before bedtime), starting from the 5th day of the menstrual cycle, for 5 days.

Preliminary determine the content of estrogens in the body. If there is no effect, the treatment is repeated, spending 3 to 5 courses, increasing the daily dose to 75-100 mg or increasing the course duration to 10 days. The course dose of the drug should not be more than 500 mg.