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Description of the medicine: Oxyprogesterone capronate (Oxyprogesteroni caproas)

OXYPROGESTERON CAPRONATE (Oxyprogesteroni caproas).

Pregnen-4-ol-17 a-dione-3, 20 capronate, or 17 a -oxy-4-pregnen-3, 20-dione 17-hexanoate.

Synonyms: Hormofort, Caposten, Caprosteron, Capton, Delalutin, Depolut, Eslralutin, Hormofort, Hydroxyprogesterone caproate, Hydroxyprogesteroni caproas, Neolutin, Primolut-Depot, Progesteron-retard, Prolutin-Depot, Syngynon and others.

Crystalline powder, white or white with a slightly yellowish tint. Practically insoluble in water, soluble in alcohol, fatty oils. 17 a - Oxyprogesterone capronate is a synthetic analogue of the corpus luteum hormone progesterone. It is chemically different from progesterone in that in position C 17 it contains a caproic acid residue. Being an ester of oxyprogesterone, oxyprogesterone capronate is more resistant in the body than progesterone, it acts more slowly and has a prolonged effect. After a single intramuscular injection of an oxyprogesterone capronate oil solution, its effect lasts from 7 to 14 days.

By the biological properties of oxyprogesterone, capronate is similar to progesterone. Used in pathological processes associated with insufficiency of the corpus luteum. Intramuscularly administered as a solution in oil.

In order to prevent and treat a threatening and beginning miscarriage, 0.125 - 0.25 g (1 - 2 ml of 12.5% ​​solution) is administered once a week. Oxyprogesterone capronate is used only in the first half of pregnancy.

With amenorrhea (primary and secondary), oxyprogesterone capronate is prescribed immediately after the use of estrogen preparations is discontinued; 0.25 g is administered once or in two divided doses.

For the treatment of dysfunctional uterine bleeding, oxyprogesterone capronate is less convenient than progesterone, since its effect dulls us slowly; oxyprogesterone capronate can, however, be used to normalize the cycle. It is recommended to administer the drug in a dose of 0.0625 - 0.125 g (0.5 - 1, 0 ml of 12.5% ​​solution) on the 20th - 22nd day of the cycle.

Oxyprogesterin capronate is also used in the treatment of patients with cancer of the uterus, breast and some other malignant tumors. A 25% solution of 3-4 ml is administered intramuscularly daily or every other day for a long period (30 to 300 days).

Release form: 12, 5% (0.125 g) and 25% (0.25 g) solutions of hydroxyprogesterone capronate in oil in ampoules containing 1 ml.

Storage: List B. In the dark place. Ampoules are stored at a temperature not lower than About C. In the event of precipitation of crystals in the ampoule, the ampoule is heated in a boiling bath with shaking. If the crystals disappear and the solution becomes transparent, and when cooled to + 36 - 38 ° C, the crystals do not fall out again, the solution is suitable for use.

Rp .: Sol. Oxyprogesteroni caproatis oleosae 12, 5% 1 ml

DtdN 10 in ampull.