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Medication Description: Oxyprogesterone Capronate (Oxyprogesteroni caproas)

OXIPROGESTERONE KAPRONAT (Oxyprogesteroni caproas).

Pregnen-4-ol-17 a -dione-3, 20 capronate, or 17 a-hydroxy-4-pregnene-3, 20-dione 17-hexanoate.

Synonyms: Hormofort, Caposten, Caprosteron, Capton, Delalutin, Depolut, Eslralutin, Hormofort, Hydroxyprogesterone caproate, Hydroxyprogesteroni caproas, Neolutin, Primolut-Depot, Progesteron-retard, Prolutin-Depot, Sy

White or white with a slightly yellowish sheen crystalline powder. Practically insoluble in water, soluble in alcohol, fatty oils. 17 a - Oxyprogesterone capronate is a synthetic analogue of the corpus luteum hormone - progesterone. Chemically different from progesterone in that in position C 17 contains a residue of caproic acid. Being an oxyprogesterone ester, oxyprogesterone capronate is more stable in the body than progesterone, it acts slower and has a prolonged effect. After a single intramuscular injection of an oil solution of hydroxyprogesterone capronate, its action lasts from 7 to 14 days.

The biological properties of hydroxyprogesterone capronate are similar to progesterone. Applied with pathological processes associated with insufficiency of the corpus luteum. Enter intramuscularly in the form of a solution in oil.

For the purpose of prophylaxis and treatment of a threatening and started miscarriage, 0.125-0.25 g (1-2 ml of a 12.5% ​​solution) is administered once a week. Oxyprogesterone capronate is used only in the first half of pregnancy.

For amenorrhea (primary and secondary), oxyprogesterone capronate is prescribed immediately after stopping the use of estrogenic drugs; enter 0.25 g once or twice.

For the treatment of dysfunctional uterine bleeding of oxyprogesterone capronate, it is less convenient than progesterone, since its effect diminishes us slowly; oxyprogesterone capronate can, however, be used to normalize the cycle. It is recommended to administer the drug in a dose of 0.0625 - 0.125 g (0.5 - 1, 0 ml of 12, 5% solution) on the 20th - 22nd day of the cycle.

Oxyprogesterol capronate is also used in the treatment of patients with cancer of the uterus, breast cancer and with some other malignant tumors. A 25% solution of 3-4 ml is administered intramuscularly daily or every other day for a long period (30-300 days).

Product form: 12, 5% (0.125 g) and 25% (0.25 g) solutions of oxyprogesterone capronate in oil in ampoules containing 1 ml each.

Storage: List B. In the dark spot. The ampoules are kept at a temperature not lower than 0 ° C. In case of crystals falling out in the ampoule, the ampoule is heated in a boiling bath with shaking. If the crystals disappear and the solution becomes transparent, and when cooled to + 36 - 38 C, the crystals will not fall out again, the solution is suitable for use.

Rp .: Sol. Oxyprogesteroni caproatis oleosae 12, 5% 1 ml

DtdN 10 in ampull.