Description medications: Fosfaden (Phosphadenum)
Adenosine-5'-monophosphate acid or phosphoric ester 9- b -D-ribofuranoside adenine.
Synonyms: Aden, AMP, AMP, Adenil, Adenovite, Adenyl, USAID, Cardiomone, Fosfostimol, Monophosaden, Phosaden , Vitamin B8.
The white crystalline powder and odorless. It is soluble in water, soluble in 1% sodium hydrogen carbonate solution.
Fosfaden (AMP) can be regarded as a fragment of adenosine triphosphate (ATP). AMP is part of a series of co-enzymes that regulate the redox processes (see. Flavinat, Kobamamid.). Participates in the normalization of porphyrin biosynthesis. It has a vasodilating effect. It has antiagregatsionnogo properties.
Applied in the treatment of acute intermittent porphyria and lead poisoning with severe polinevroticheskim syndrome, chronic occlusive disease, thrombophlebitis, chronic venous insufficiency, venous thrombosis; sometimes with coronary heart disease.
There is evidence of improvement in the condition of patients in the treatment of psoriasis fosfadenom, as well as patients with diabetic retinopathy.
In duodenal ulcer acceleration noted regression of the ulcer and a tendency to normalization of immunologic parameters (im 1% solution of 5 ml, 2 times a day for 10 to 12 days). Significant influence on the acid-forming and secretory function were observed.
Applied fosfaden into tablets (regardless of the meal) and intramuscularly in the form of the disodium salt solution.
In acute porphyria initially administered intramuscularly, starting from 0.06 g (3 ml of 2% solution) 5 times a day, gradually reducing the dose to 0.06 g of 2 times a day, and then move on ingestion of the preparation to 0.05 g 2 times a day; It takes a long time (depending on the patient's condition).
When peripheral vascular diseases administered intramuscularly to 0.04 g (2 ml rastvera 2%) 2 - 3 times a day (2 - 4 weeks), and then inside of 0.05 g of 2 - 3 times a day.
In chronic ischemic heart disease, administered intramuscularly at 0.04 g 3 - 4 times a day for 25 - 30 days, then allowed inside of 0.05 g 4 times a day.
In other diseases 0,025- designate the interior of 0.05 g (0.15 grams per day) or intramuscularly 0.02-0.04 g (0.12 grams per day) during 2 - 4 weeks.
In ophthalmic practice fosfaden used inside of 0.05 g 2 times a day, as well as retrobulbar injection.
When receiving fosfadena inside may cause nausea, dizziness, tachycardia, allergic reactions; in these cases, reduce the dose or stop the continued application of the drug.
Method of issuance: pills to 0,025 and 0.05 grams in a package of 30 pieces or orange glass jars of 50 pieces; 2% injection (Solutio Phosphadeni 2% Pro injectionibus; pH 6, 7 - 7, 5) in a package of 10 vials.
Storage: dry (tablets), protected from light.