Description medications: Unitiol (Unithiolum)

Unitiol (Unithiolum). 2, 3-Dimerkaptopropansulfonat sodium.

Synonyms: Dimaval, Unitiol.

White or white with a slightly kremovatym crystalline powder with a very slight odor of mercaptan. The easily soluble in water, slightly in alcohol. The solution of the drug - a colorless or pinkish color transparent liquid with a slight odor of mercaptan; pH of 5% solution of 3, 1 - 5, 5. sterilized at + 100 'C for 30 min.

By building and pharmacological properties, unitiol close to ditioglitserinu or 2, 3-dimercaptopropanol, produced abroad under the title: BAL (British antilyuizit, VAL) Antoxol, Dicaptol, Dimercaprol, Dimersarrolum, Dithioglycerin.

Unitiol used for the treatment of acute and chronic poisoning arsenic, mercury, chromium, bismuth and other metals belonging to the so-called thiol poisons, t. E. Agents capable of reacting with the sulfhydryl (thiol) groups of proteins and to inactivate enzyme of. Less active unitiol of lead poisoning.

Unitiol, like BAL, contains two sulfhydryl groups. On the mechanism of action of these drugs are close to kompleksonam. Their active sulfhydryl groups react with thiol poisons which are in the blood and tissues, and form non-toxic complexes with them, which are excreted in urine. Binding poison leads to restoration of function of enzyme systems of the body affected by the poison.

The same mechanism of action gave rise to the application of unitiola and BALF in the treatment gepatotserebralnoy degeneration (Wilson's disease - Westphal - Konovalova) in the pathogenesis of which play a role violations exchange copper in the body and the accumulation of the metal in the subcortical nuclei.

Apply unitiol for poisoning cardiac glycosides, as well as in the treatment of chronic alcoholism.

Compared with BAL unitiol less toxic; good solubility in water, a great convenience for use, and provides more rapid absorption of the drug (BAL slightly soluble in water and applied intramuscularly in the form of oil solutions).

For the treatment of acute and chronic intoxications of arsenic and mercury compounds, unitiol administered intramuscularly or subcutaneously in the form of a 5% aqueous solution in an amount of 5 - 10 ml (per 0.05 g or 1 ml of a 5% solution of 10 Kg patient body weight) . Treatment should be initiated as early as possible. When poisoning injection arsenic make the first day every 6 - 8 hours (3 - 4 injections per day depending on the patient) on the second day 2 - 3 injections every 8 - 12 hours in the following - and 1 - 2 injections per day. When compounds of mercury poisoning, the injections made by the same scheme for 6 -7 days. Children drug appoints smaller doses according to age.

The time of application depends on the rate of excretion of toxic substances from the body. Treatment is carried out until the disappearance of symptoms of intoxication. When poisoning mercury salts are administered for at least 6 days.