Description of the medicine: Pyracetamum

PYRACETAM (Pyracetamum). 2-Oxo-1-pyrrolidinylacetamide.

Synonyms: Nootropil, Pyramem, Apagan, Breinox, Cerebropan, Ceretran, Ciclocetam, Cintilan, Dinacel, Dinagen, Encefalux, Eumental, Euvifor, Fortineural, Gabacet, Gericetam, Merapiran, Neutrofin, Noocebril, Noocefal, Nootropil, Normarbrain, Norotrop, Norzetam, Piramem, Piratam, Pirroxil, Pyramem, Stimubral, Stimocartex and others.

White or almost white crystalline powder. Easily soluble in water, soluble in alcohol; PH of aqueous solutions is 5, 0 - 7, 0.

Pyracetam is the main representative of a group of nootropic drugs. Currently, a number of his immediate analogues and homologues (etiracetam, oxyracetam, etc.), similar to him in effect, have been synthesized, however, piracetam continues to be the main drug of this group.

Pyracetam is well absorbed when taken orally. When introduced into the body, it penetrates into various organs and tissues, including brain tissue. Virtually not metabolized. It is excreted by the kidneys.

Pyracetam has a positive effect on the metabolic processes and blood circulation of the brain. Stimulates oxidation-reduction processes, enhances the utilization of glucose, improves regional blood flow in ischemic areas of the brain. The drug increases the energy potential of the body by accelerating the turnover of ATP, increasing the activity of adenylate cyclase and inhibiting the nucleotide phosphatase. Improvement of energy processes under the influence of pyracetam leads to an increase in the stability of brain tissue during hypoxia and toxic effects. There are data on the amplification, under the influence of pyracetam, of the synthesis of nuclear RNA in the brain.

The drug is very little toxic (in acute animal experiments, the lethal dose exceeds 10 g / kg when injected into a vein).

The therapeutic properties of piracetam are determined by its ability to improve the integrative activity of the brain, promote memory consolidation, improve learning processes, restore and stabilize impaired brain functions.

Applied pyracetam in adults and children with various diseases of the nervous system, especially associated with vascular disorders and pathology of brain metabolic processes, including in elderly and senile people.

In neurological practice, they are prescribed for cerebral atherosclerosis, vascular parkinsonism and other diseases with chronic cerebral vascular insufficiency, manifested in memory, attention, speech, dizziness, etc., as well as changes in cerebral circulation, comatose and subcomatose states after Brain trauma and intoxication, as well as during the period of rehabilitation therapy after such conditions. Piracetam is also used in diseases of the nervous system, accompanied by a decrease in intellectual function and impaired emotional-volitional sphere.