Description of the medicine: Aminalonum (Aminalonum)
AMINALON (Aminalonum). G - Aminobutyric acid.
Synonyms: Gamalon, Ganevrin, Apogamma, Encefalon, GABA, Gaballon, Gamarex, Gammalon, Gammaneuron, Gammar, Gammasol, Mielogen, Mielomade and others.
A white crystalline powder with a slightly bitter taste and a weak specific odor. Easily soluble in water, very slightly soluble in alcohol; PH 5% aqueous solution 6, 5 - 7, 5. g - Aminobutyric acid (GABA) is a biogenic substance. Contained in the central nervous system and takes part in the neurotransmitter and metabolic processes in the brain.
It is established that GABA is the main mediator involved in the processes of central inhibition.
Under the influence of GABA, the energy processes of the brain are activated, the respiratory activity of tissues increases, the utilization of glucose by the brain improves, the blood supply improves.
The effect of GABA in the central nervous system is realized through its interaction with specific GABAergic receptors, which recently are divided into GABA-A and GABA-B receptors, etc. In the mechanism of action of a number of central neurotropic substances (hypnotics, anticonvulsants, convulsants, etc.) An important role is played by their agonistic or antagonistic interaction with GABA receptors. A close relationship has been established between GABAergic and benzodiazepine receptors. Benzodiazepines potentiate the action of GABA.
The presence of GABA in the central nervous system was discovered in the mid-1950s, and soon it was synthesized. In the late 60s, under the name "Gamalon", GABA was proposed for use as a medicinal product abroad, then - under the name "Aminalon" - in our country.
According to experimental data, GABA penetrates badly through the blood-brain barrier when it enters the body. However, when GABA is used for medical purposes in the presence of cerebral pathology, it is established that it improves the dynamics of the nervous processes in the brain, thinking, memory, and has a mild psycho-stimulating effect.
As a drug, aminalone has been used mainly in geriatric practice and in the treatment of children with mental retardation. By the nature of the therapeutic effect, the drug approaches nootropic drugs. Its effect develops slowly, a relatively long course of its application is required. Despite the appearance of new nootropic drugs, which in some cases give a more pronounced effect (piracetam, etc.), aminalone did not lose its therapeutic value.
Aminolone is used for vascular diseases of the brain (atherosclerosis, hypertensive disease), chronic cerebrovascular insufficiency with memory, attention, speech, dizziness and headache, with dynamic disorders of cerebral circulation, and after a stroke and brain injuries in order to increase motor and mental Activity of patients.