Description of the medicine: Amphoglucamine (Amphoglucaminum)
A mixture of the N-methylglucamine salt of amphotericin B with N-methylglucamine.
Amorphous powder of yellow color. Soluble in water. Hygroscopic. It is easily inactivated in light and at elevated temperature, as well as in acidic (pH below 2, 0) and alkaline (pH above 12, 0) media.
According to the spectrum of antifungal action, the drug corresponds to amphotericin B. It is effective when ingested and relatively well tolerated.
Amphoglucamine is prescribed for candidiasis of the gastrointestinal tract, intestinal candidosis, candidiasis of internal organs, chronic and granulomatous disseminated forms of candidiasis, as well as for coccidioidosis, cryptococcosis, blastomycosis and other indications for the use of amphotericin B.
Assign Amphoglucamine to adults inside starting with 200,000 units 2 times a day (after meals); With insufficient effect and good tolerability, increase the dose to 500 000 units 2 times a day.
The course of treatment with localized forms of candidiasis usually lasts 10 to 14 days, with common forms and deep mycoses - up to 3 to 4 weeks.
Children are prescribed 2 times a day (after meals) in the following single doses: at the age of 2 years - 25 000 units (1/4 tablets), 2-6 years - 100 000 units (1 tablet), 6 - 9 years - 150 000 units, 9 - 14 years - 200 000 units, over 14 years - in the same dose as adults.
If necessary and no side effects, the course of treatment can be repeated after a 5 to 7-day break.
There are data on the successful use of amphoglucamine in the treatment of pneumomycosis, candidiasis of the nasopharynx and other fungal diseases.
Contraindications and precautions are the same as in the treatment of amphotericin B.
Form release: tablets of 0.1 g (10 000 units) in a package of 10 and 40 pieces.
Storage: List B. In dry, the dark place at a temperature of not more than + 4 C.