Description of the medicine: Co-trimoxazole (Co-trimoxazolum)
Combined preparation containing two active substances: sulfanilamide preparation sulfamethoxazole and diaminopyrimidine derivative - trimethoprim.
Synonyms: Apo-Sulfatrim, Baktekod, Bactoreptide, Bactrim, Berlocid, Bicotrim, Biseptol, Bisutrim, Gen Ultrasol, Grosseptol, Duo-Septol, Intrim, Cotrim, Cotrimoxazole, Cotrimol, Cotripharm, Novo-Trimel, Oriibact, Oriprim, Septrin, Sinersul, Sulotrim, Sulfamethoxazole and Trimethoprim, Sulfatrim, Sumetrolim, TMS 480, Trim, Trimesol, Trimosul, Ciplin, Exposol, Abactin, Abactrim, Andoprim, Aposulfatrim, Apo-Sulfatrim, Bactecod, Bactramin, Bacterial, Bactrimel, Bactrisol, Bacticel, Bactofer , Bactoreduct, Bactrim, Berlocid, Bicotrim, Biseptol, Bisutrim, Chemitrin, Ciplin, Cotrim, Cotrimol, Cotrimoxazol, Cotripharm, Doctonil, Duo-Septol, Ectapprim, Espectrin, Expozol, Falprin, Gantrin, Gen-Ultrazol, Groseptol, Infectrim, Intrim , Metomide, Microcetim, Nolapse, Novo-Trimel, Oradin, Oribact, Oriprim, Potesept, Primazol, Rancotrim, Resprim, Septocid, Septrin, Sinersul, Sulotrim, Sumetrolim, TMS 480, Trim, Sulfamethoxazole and Trimethoprim, Trimexazol, Trimezol, Trimosul, Trixazol, Uroxen, Vanadyl, and others.
Sulfamethoxazolum (Sulfamethoxazolum). 3- (p-Aminobenzenesulfamido) -5-methylisoxazole.
Synonyms: Gantanol, Metoxal, Radonil, Sunomin, Sulfamethoxazole, Sulfamethylisoxazole, Sulfisomezole, Sulphamethoxazole.
It is an antibacterial drug similar in chemotherapeutic activity to other sulfanilamide preparations.
Trimethoprimum. 2, 4-Diamino-5- (3,4,5-trimethoxybenzyl) -pyrimidine.
Synonyms: Metopicide, Syraprim, Trimethoprim.
The chemical structure is close to the chloride (see). Has antibacterial activity.
The combination of these two drugs, each of which has a bacteriostatic effect, provides high bactericidal activity against gram-positive and gram-negative microorganisms, including bacteria resistant to sulfanilamide preparations.
The bactericidal effect is associated with the double blocking action of bactrim on the metabolism of bacteria. Sulfamethoxazole disrupts the biosynthesis of dihydrofolic acid, and trimethoprim blocks the next stage of metabolism, the reduction of dihydrofolic acid into tetrahydrofolic acid, necessary for the development of microorganisms. The choice of sulfamethoxazole as a component of bactrim is due to the fact that it has the same elimination rate with trimethoprim.
The drug is available in tablets in two dosages: for adults with 0.4 mg (400 mg) of sulfamethoxazole in one tablet and 0.08 g (80 mg) of trimethoprim; For children with 100 mg of sulfamethoxazole in a single tablet and 20 mg of trimethoprim.
For adults, tablets of "Bactrim forte" containing 800 mg of sulfamethoxazole and 160 mg of trimethoprim are also produced, and for children a syrup containing 1 mg of sulfamethoxazole and 8 mg of trimethoprim (a suspension of white with a yellowish hue in 100 bottles Ml).
The drug is effective against streptococci, staphylococci, pneumococci, rods of dysentery, typhoid, E. coli, protea; Ineffective against mycobacteria tuberculosis, spirochaete, Pseudomonas aeruginosa.
The drug is rapidly absorbed when taken orally. The maximum concentration in the blood is noted 1 to 3 hours after administration and persists for 7 hours. High concentrations are created in the lungs and kidneys.